The gut microbiome-bile acid axis in hepatocarcinogenesis - 19/12/20

Doi : 10.1016/j.biopha.2020.111036

Liwei Wu ^a,^b, Jiao Feng ^b, Jingjing Li ^a,^b, Qiang Yu ^b, Jie Ji ^b, Jianye Wu ^a,⁎ , Weiqi Dai ^a,^b,^c,^d,^e,⁎ , Chuanyong Guo ^a,^b,⁎
^a Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China
^b Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
^c Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai 200032, China
^d Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China
^e Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, China

^⁎Corresponding author at: Department of Gastroenterology, Putuo People's Hospital, NO. 1291, Jiangning road, Putuo, Shanghai 200060, China.Department of GastroenterologyPutuo People's HospitalNO. 1291Jiangning roadPutuoShanghai200060China^⁎⁎Corresponding author at: Department of Gastroenterology, Shanghai Tenth People’s Hospital, NO. 301, Middle Yanchang road, Jing’an, Shanghai 200072, China.Department of GastroenterologyShanghai Tenth People’s HospitalNO. 301Middle Yanchang roadJing’anShanghai200072China

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Highlights

•	Altered BA levels may promote tumorgenesis.
•	Gut microbiome is correlate with and mediate the onset of HCC.
•	BAs metabolism is greatly regulated by gut microbiome.
•	Restoring BA signaling by correcting dysbiosis may be helpful for inhibiting HCC.

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Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related deaths globally, with few effective therapeutic options. Bile acids (BAs) are synthesized from cholesterol in the liver and can be modulated by farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (GPBAR1/TGR5). Alterations in BAs can affect hepatic metabolic homeostasis and contribute to the pathogenesis of liver cancer. Increasing evidence points to the key role of bacterial microbiota in the promotion and development of liver cancer. They are also involved in the regulation of BA synthesis and metabolism. The purpose of this review is to integrate related articles involving gut microbiota, BAs and HCC, and review how the gut microbiota-BA signaling axis can possibly influence the development of HCC.

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Keywords : Gut microbiome, Bile acids, Hepatocellular carcinoma

Plan

Introduction

BAs in Hepatocarcinogenesis

BA metabolism is regulated by the microbiome

Gut microbiome in liver cancer

Microbiome/BA axis in HCC

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Article 111036- janvier 2021 Retour au numéro

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The gut microbiome-bile acid axis in hepatocarcinogenesis - 19/12/20

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