Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder - 08/01/21
, Takashi Itahashi, PhD d, F. Xavier Castellanos, MD a, c, Simon B. Eickhoff, MD f, gAbstract |
Objective |
To conduct a meta-analysis of resting-state functional magnetic resonance imaging (R-fMRI) studies in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and in adults with ADHD to assess spatial convergence of findings from available studies.
Method |
Based on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases were searched up to April 9, 2019, with no language or article type restrictions. Study authors were systematically contacted for additional unpublished information/data. Resting-state functional magnetic resonance imaging studies using seed-based connectivity (SBC) or any other method (non-SBC) reporting whole-brain results of group comparisons between participants with ADHD and typically developing controls were eligible. Voxelwise meta-analysis via activation likelihood estimation with cluster-level familywise error (voxel-level: p < .001; cluster-level: p < .05) was used.
Results |
Thirty studies (18 SBC and 12 non-SBC), comprising 1,978 participants (1,094 with ADHD; 884 controls) were retained. The meta-analysis focused on SBC studies found no significant spatial convergence of ADHD-related hyperconnectivity or hypoconnectivity across studies. This nonsignificant finding remained after integrating 12 non-SBC studies into the main analysis and in sensitivity analyses limited to studies including only children or only non–medication-naïve patients.
Conclusion |
The lack of significant spatial convergence may be accounted for by heterogeneity in study participants, experimental procedures, and analytic flexibility as well as in ADHD pathophysiology. Alongside other neuroimaging meta-analyses in other psychiatric conditions, the present results should inform the conduct and publication of future neuroimaging studies of psychiatric disorders.
Le texte complet de cet article est disponible en PDF.Key words : ADHD, ALE, meta-analysis, neuroimaging, resting state
Plan
| Drs. Cortese and Aoki contributed equally to this article. |
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| This work was partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant number 18K15493 to Y.Y.A. and grant numbers 19K03370 and 19H04883 to T.I.), the Takeda Science Foundation (to Y.Y.A.), the SENSHIN Medical Research Foundation (to Y.Y.A.), the Deutsche Forschungsgemeinschaft (DFG; grant number EI 816/11-1), the National Institute of Mental Health (NIMH; grant number R01-MH074457), the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain,” and the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 945539 (HBP SGA3) (to S.B.E.) and R61MH113663 (to F.X.C.). |
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| This article is part of a special series devoted to the subject of child and adolescent attention-deficit/hyperactivity disorder (ADHD). The series covers a range of topics in the area including genetics, neuroimaging, treatment, and others. The series was edited by Guest Editor Jonathan Posner, MD. |
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| Dr. Eickhoff served as the statistical expert for this research. |
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| Author Contributions Conceptualization: Cortese, Castellanos Data curation: Cortese, Aoki, Itahashi Formal analysis: Itahashi, Eickhoff Investigation: Aoki Methodology: Cortese, Aoki, Castellanos, Eickhoff Project administration: Cortese Software: Itahashi, Eickhoff Supervision: Cortese, Castellanos, Eickhoff Writing – original draft: Cortese Writing – review and editing: Aoki, Itahashi, Castellanos, Eickhoff |
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| ORCID Samuele Cortese, MD, PhD: 0000-0001-5877-8075 Yuta Y. Aoki, MD, PhD: https://orcid.org/0000-0001-5617-4948 Takashi Itahashi, PhD: https://orcid.org/0000-0001-7606-7090 F. Xavier Castellanos, MD: 0000-0001-9192-9437 Simon B. Eickhoff, MD: https://orcid.org/0000-0001-6363-2759 |
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| The authors wish to thank the following colleagues, for providing unpublished information/data: Deborah Dewey, PhD, of the University of Calgary; Damien Fair, PhD, of the Oregon Health and Science University; Susan Shur-Fen Gau, MD, PhD, of the National Taiwan University; Jae-Won Kim, MD, PhD, of the Seoul National University College of Medicine; Maarten Mennes, PhD, of the Donders Institute for Brain, Cognition and Behaviour, Radboud University; Jeanette Mostert, PhD, of the Radboud University Medical Center, Nijmegen; Pruim Prum, PhD, of the Donders Institute for Brain, Cognition and Behaviour; Li Sun, PhD, of the Northeastern University; Zang Yu-Feng, MD, of the Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University; Sarah L. Karalunes, PhD, of the Oregon Health and Science University; Ayaka Ishii-Takahashi, MD, PhD, of the University of Tokyo; Aaron Kucyi, PhD, of the Northeastern University; Eve M. Valera, PhD, of the Harvard Medical School; Qian Xing, PhD, of the National University of Singapore; Juan Helen Zhou, PhD, of the National University of Singapore; Aaron Mattfeld, PhD, of the Florida International University. |
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| Disclosure: Dr. Cortese has served as deputy editor of Evidence-Based Mental Health, as associate editor of Child and Adolescent Mental Health, and on the editorial boards of the Journal of Child Psychology and Psychiatry, the Journal of Child and Adolescent Psychopharmacology, and CNS Drugs. He has received honoraria for talks on ADHD from the Association for Child and Adolescent Mental Health, the British Association for Psychopharmacology, the Canadian ADHD Resource Alliance, and the Healthcare Convention. Dr. Castellanos has served as a member of the scientific advisory council for BOL Pharma, Israel. Drs. Aoki, Itahashi, and Eickhoff have reported no biomedical financial interests or potential conflicts of interest. |
Vol 60 - N° 1
P. 61-75 - janvier 2021 Retour au numéro
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