Risk factors for frontal fibrosing alopecia: A case-control study in a multiracial population - 15/02/21
, Alessandra Anzai, MD b, Bruna Duque-Estrada, MD c, Debora Cadore Farias, MD d, Daniel Fernandes Melo, MD, MSc e, Fabiane Mulinari-Brenner, MD, MSc f, Giselle Martins Pinto, MD g, Leonardo Spagnol Abraham, MD, MSc h, Leopoldo Duailibe Nogueira Santos, MD i, Rodrigo Pirmez, MD c, Hélio Amante Miot, MD, PhD aAbstract |
Background |
Frontal fibrosing alopecia (FFA) is a chronic cicatricial alopecia with unknown etiology and a worldwide rising incidence.
Objective |
The objective of this study was to evaluate the association of FFA with demographic and exposure factors in a Brazilian multiracial population.
Methods |
A multicenter case-control study was conducted in 11 referral centers throughout Brazil. The study was a case-control study that prospectively recruited 902 participants (451 patients with FFA and 451 sex-matched control individuals). Study participants completed a thorough questionnaire comprising variables grouped as baseline demographics, environmental exposure, diet, hormonal factors, allergies, and hair and skin care.
Results |
When adjusted by sex, age, menopause, and skin color, FFA was associated with hair straightening with formalin (odds ratio [OR], 3.18), use of ordinary (nondermatologic) facial soap (OR, 2.09) and facial moisturizer (OR, 1.99), thyroid disorders (OR, 1.69), and rosacea (OR, 2.08). Smokers (OR, 0.33) and users of antiresidue/clarifying shampoo (OR, 0.35) presented a negative association with FFA. There was no association with the use of sunscreen.
Limitations |
Recall bias.
Conclusions |
The association with moisturizers, ordinary facial soap, and hair straightening with formalin and the negative association with antiresidue/clarifying shampoo reinforce the possibility of an exogenous particle triggering FFA.
Le texte complet de cet article est disponible en PDF.Key words : case-control, frontal fibrosing alopecia, risk factors, sunscreens, tobacco
Abbreviations used : CI, FFA, HLA, IL, OR, Th
Plan
| Funding sources: None. |
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| Conflicts of interest: None disclosed. |
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| Abstract presented at 24th World Congress of Dermatology, Milan, Italy, 2019. |
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| IRB approval status: Reviewed and approved by the Universidade Estadual Paulista IRB. |
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| Reprints not available from the authors. |
Vol 84 - N° 3
P. 712-718 - mars 2021 Retour au numéro
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