Frontal fibrosing alopecia (FFA) is a chronic cicatricial alopecia with unknown etiology and a worldwide rising incidence.
The objective of this study was to evaluate the association of FFA with demographic and exposure factors in a Brazilian multiracial population.
A multicenter case-control study was conducted in 11 referral centers throughout Brazil. The study was a case-control study that prospectively recruited 902 participants (451 patients with FFA and 451 sex-matched control individuals). Study participants completed a thorough questionnaire comprising variables grouped as baseline demographics, environmental exposure, diet, hormonal factors, allergies, and hair and skin care.
When adjusted by sex, age, menopause, and skin color, FFA was associated with hair straightening with formalin (odds ratio [OR], 3.18), use of ordinary (nondermatologic) facial soap (OR, 2.09) and facial moisturizer (OR, 1.99), thyroid disorders (OR, 1.69), and rosacea (OR, 2.08). Smokers (OR, 0.33) and users of antiresidue/clarifying shampoo (OR, 0.35) presented a negative association with FFA. There was no association with the use of sunscreen.
The association with moisturizers, ordinary facial soap, and hair straightening with formalin and the negative association with antiresidue/clarifying shampoo reinforce the possibility of an exogenous particle triggering FFA.Le texte complet de cet article est disponible en PDF.
Key words : case-control, frontal fibrosing alopecia, risk factors, sunscreens, tobacco
Abbreviations used : CI, FFA, HLA, IL, OR, Th
| Funding sources: None.
| Conflicts of interest: None disclosed.
| Abstract presented at 24th World Congress of Dermatology, Milan, Italy, 2019.
| IRB approval status: Reviewed and approved by the Universidade Estadual Paulista IRB.
| Reprints not available from the authors.