Pediatric Cerebral Cavernous Malformations - 17/02/21
, Sarah Lanham, MB, ChB c, Kanwar Gill, MB, ChB, MRCP a, Saurabh Sinha, BM, BCh, MA d, e, Daniel J.A. Connolly, MB, ChB, BSc, MRCP c, fAbstract |
Cerebral cavernous malformations are the second most common vascular malformations in the central nervous system, and over one-third are found in children. Lesions may be solitary or multiple, be discovered incidentally, be sporadic, or be secondary to familial cavernomatosis or radiation therapy. Children may present with focal seizures, intracranial hemorrhage, or focal neurological deficits without radiological evidence of recent hemorrhage. We present several children with cerebral cavernous malformations and explore the challenges of their diagnosis in children, their key imaging features, the role of follow-up imaging, and their subsequent management including stereotactic radiosurgery and microsurgical resection. Individual patient risk stratification is advocated for all affected children and their families.
Le texte complet de cet article est disponible en PDF.Keywords : Cerebral cavernous malformation, Vascular malformations, Child, Seizures, Intracranial hemorrhage, Neurosurgery
Plan
| Declaration of funding source: None. |
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| Declarations of interest: None. |
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| Author contributions: Guarantor of integrity of the entire study: M.P. Study concepts and design: M.P. Literature research: M.P. and S.L. Clinical studies–M.P., K.G., S.S., and D.J.A.C. Experimental studies/data analysis: n/a. Statistical analysis: n/a. Manuscript preparation: M.P. and S.L. Manuscript editing–M.P., S.L., K.G., S.S., and D.J.A.C. M.P.: Reported the neuroimaging; co-wrote and edited the manuscript text; extracted, reformatted, and labeled all figures; wrote the figure legends. S.L.: Co-wrote and edited the manuscript text. K.G.: Reported the neuroimaging, extracted the relevant images, and edited the manuscript text. S.S.: Involved in direct patient care and edited the manuscript text. D.J.A.C.: Reported the neuroimaging, wrote the figure legends, and edited the manuscript text. |
Vol 116
P. 74-83 - mars 2021 Retour au numéro
Article précédent
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