Fourier Analysis on Regular and Irregular Astigmatism of Anterior and Posterior Corneal Surfaces in Fuchs Endothelial Corneal Dystrophy - 16/03/21
, Yuichi Yasukura a, Nozomi Nishida a, Shizuka Koh a, Ryo Kawasaki a, Naoyuki Maeda a, Vishal Jhanji b, Kohji Nishida aAbstract |
Purpose |
To conduct Fourier analysis on regular and irregular astigmatism of the anterior and posterior corneal surfaces using anterior segment optical coherence tomography in patients with Fuchs endothelial corneal dystrophy (FECD)
Design |
Observational case series.
Methods |
This study included 75 eyes of 43 FECD patients and 34 eyes of 34 healthy subjects in Osaka University Hospital. Corneal dioptric data from the central 6-mm zone of the anterior and posterior corneal surface were expanded into spherical, regular astigmatism, asymmetry, and higher-order irregularity components using Fourier analysis. We analyzed the association between each component and modified Krachmer grade.
Results |
There were significant differences in regular astigmatism, asymmetry, and higher-order irregularity components of the anterior corneal surface, and spherical, regular astigmatism, asymmetry, and higher-order irregularity components of the posterior corneal surface among modified Krachmer grades (P = .036, <.001, <.001, <.001, <.001, <.001, and <.001, respectively). Asymmetry component of the anterior and posterior corneal surfaces gradually increased with FECD progression. Higher-order irregularity components of the anterior and posterior corneal surfaces drastically increased in Grade 6. Many eyes had an axis of 0°-180° for the asymmetry component of the anterior surface and 180°-360° for that of the posterior surface.
Conclusion |
Patients with severe FECD had a larger amount of asymmetry and higher-order irregularity components of the anterior and posterior corneal surfaces. Patients with FECD up to Grade 5 were characterized by anterior and posterior flattening in the inferior cornea, and those with Grade 6 showed irregularity in the anterior and posterior corneal surfaces.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Asymmetry and higher-order irregularity by Fourier analysis increased in Fuchs endothelial corneal dystrophy (FECD). |
• | Moderate FECD patients have inferior flattening of anterior and posterior cornea. |
• | Severe FECD patients are characterized by irregularity of anterior and posterior cornea. |
• | Better corrected distance visual acuity (CDVA) was significantly associated with a steeper spherical component, and smaller amounts of asymmetry in the anterior corneal surface. |
• | Better CDVA was associated with a steeper spherical component, a smaller amount of asymmetry, and a higher-order irregularity component in the posterior corneal surface. |
Plan
Vol 223
P. 33-41 - mars 2021 Retour au numéro
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