Adenosquamous carcinoma: An aggressive histologic sub-type of colon cancer with poor prognosis - 18/03/21
, Brian Cox a, Wesley Shen a, b, Ruoyan Zhu a, b, Isabella Stettler a, b, Jason Cohen a, b, Avo Artinyan c, d, Alexandra Gangi aAbstract |
Background |
Studies have reported worse overall survival (OS) for adenosquamous carcinoma (ASC) compared to adenocarcinoma (AC) of the colon, but none have analyzed a national dataset for over 30 years.
Methods |
The National Cancer Database was queried from 2004 to 2016 for patients with ASC and AC of the colon. Kaplan-Meier survival analysis was performed to assess OS. Descriptive variables were evaluated using independent T-test and Chi-square analyses.
Results |
332 ASC patients were compared to 496,950 AC patients. AC patients were older than ASC patients (68.6 vs. 64.4 years); p < 0.001. Most ASC cancers presented with stage IV (41.3%) and poorly-differentiated disease (57.5%) compared to AC (22.4% and 17.7%). OS of the ASC cohort was 13.9 months. Median OS for stage IV AC versus stage IV ASC was significantly better (14.1 vs. 8.0 months); p < 0.0001.
Conclusion |
This is the largest national database study to compare ASC with AC. Our findings confirm that unlike AC, ASC most frequently presents late stage, as poorly-differentiated lesions, and have worse OS.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Adenosquamous carcinoma (ASC) is an aggressive but very rare type of colon cancer. |
• | ASC commonly presents at stage IV and as poorly-differentiated tumors. |
• | Survival is significantly worse for ASC than adenocarcinoma across all cancer stages. |
• | More aggressive treatments may be warranted for these types of malignancies. |
Keywords : Adenosquamous, Adenocarcinoma, Stage IV, Poorly-differentiated, Kaplan-meier survival
Plan
Vol 221 - N° 3
P. 649-653 - mars 2021 Retour au numéro
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