Brain Morphology Associated With Obsessive-Compulsive Symptoms in 2,551 Children From the General Population - 24/03/21
, Tonya White, MD, PhD b, Chris Vriend, PhD a, Ryan L. Muetzel, PhD b, Julia Starreveld, BSc b, Manon H.J. Hillegers, MD, PhD b, Henning Tiemeier, PhD c, Odile A. van den Heuvel, MD, PhD aAbstract |
Objective |
Obsessive-compulsive (OC) symptoms are common in the general population, but it is unclear whether subclinical OC symptoms and obsessive-compulsive disorder (OCD) are part of a neuroanatomical continuum. The goal of this study was to investigate the relation between OC symptoms and subcortical and cortical morphology in a population-based sample of children.
Method |
The study included 2,551 participants, aged 9–12 years, from the population-based Generation R Study. OC symptoms were measured using the 7-item caregiver-rated Short Obsessive-Compulsive Disorder Screener (SOCS). Structural (3T) magnetic resonance imaging scans were processed using FreeSurfer to study the thalamus and other subcortical volumes, intracranial volume, vertexwise cortical thickness, and surface area. We used linear regression models to investigate the association between OC symptoms and brain morphology. Emulating case-control studies from the literature, we compared children scoring above the clinical cutoff of the SOCS (probable OCD cases, n = 164) with matched children without symptoms.
Results |
Children with probable OCD had larger thalami compared with the control group (d 0.16, p = .044). Vertexwise analysis showed a positive association between OC symptoms and thickness of the right inferior parietal cortex, which disappeared after adjusting for total behavioral problems. SOCS scores correlated negatively with intracranial volume (B = −2444, p = .038).
Conclusion |
Children with probable OCD showed thalamus alterations similar to those previously reported in unmedicated children with OCD. OC symptoms showed a stronger association with total intracranial volume than regional brain measures. Longitudinal studies are needed to further elucidate similarities and distinctions between neural correlates of subclinical and clinical OC symptoms.
Le texte complet de cet article est disponible en PDF.Key words : FreeSurfer, MRI, OCD, neuroimaging, thalamus
Plan
| This study was supported by grants from The Netherlands Organisation for Health Research and Development (ZonMw), VIDI grant awarded to O.A. van den Heuvel (project number 91717306), VICI grant awarded to H. Tiemeier (project number 016.VICI.170.200), and MARIO study grant awarded to M.H.J. Hillegers (project number 636100004). C. Vriend received a grant from Hersenstichting, Netherlands (HA-2017-00227). R.L. Muetzel was supported by the Sophia Foundation (S18-20) and the Erasmus University Fellowship. |
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| The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, the Netherlands Organisation for Scientific Research (NWO), and the Dutch Ministry of Health, Welfare and Sport,. Neuroimaging and the neuroimaging infrastructure were supported by ZonMw TOP grant awarded to T. White (project number 91211021). Supercomputing resources were provided by NWO (www.surfsara.nl, Cartesius). |
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| Author Contributions |
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| Conceptualization: Weeland, White, Vriend, Tiemeier, van den Heuvel |
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| Data curation: Weeland, Muetzel, Starreveld |
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| Formal analysis: Weeland, Vriend, Muetzel, Starreveld, van den Heuvel |
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| Funding acquisition: Hillegers, van den Heuvel |
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| Investigation: Weeland, Vriend |
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| Methodology: Weeland, White, Vriend, Muetzel, Starreveld, Hillegers, Tiemeier, van den Heuvel |
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| Resources: White, Hillegers, Tiemeier, van den Heuvel |
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| Software: Muetzel |
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| Supervision: White, Vriend, Hillegers, Tiemeier, van den Heuvel |
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| Validation: Weeland, van den Heuvel |
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| Visualization: Weeland |
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| Writing – original draft: Weeland, White, Vriend, Muetzel, Starreveld, Hillegers, Tiemeier, van den Heuvel |
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| Writing – review and editing: Weeland, White, Vriend, Muetzel, Starreveld, Hillegers, Tiemeier, van den Heuvel |
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| ORCID |
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| Cees J. Weeland, MD: 0000-0003-1238-3769 |
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| Tonya White, MD, PhD: 0000-0003-0271-1896 |
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| Chris Vriend, PhD: 0000-0003-3111-1304 |
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| Ryan L. Muetzel, PhD: 0000-0003-3215-1287 |
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| Manon H.J. Hillegers, MD, PhD: 0000-0003-4877-282X |
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| Henning Tiemeier, PhD: 0000-0002-4395-1397 |
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| Odile A. van den Heuvel, MD, PhD: 0000-0002-9804-7653 |
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| The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam for their participation in the Generation R Study. The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam, and the Stichting Trombosedienst en Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. |
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| Disclosure: Dr. White has received grant or research support from the Sophia Children’s Hospital Foundation, the Simons Foundation Autism Research Initiative, and the Netherlands Organisation for Health Research and Development (ZonMw). She is Editor-in-Chief for Aperture: The Journal of the Organization for Human Brain Mapping, and has served on the editorial board of Neuroinformatics and is guest editing an edition on Neuroimaging in the Global Context in NeuroImage. Dr. Vriend has been listed as an inventor on a patent licensed to General Electric (WO2018115148A1). Drs. Weeland, Muetzel, Hillegers, Tiemeier, and van den Heuvel and Ms. Starreveld have reported no biomedical financial interests or potential conflicts of interest. |
Vol 60 - N° 4
P. 470-478 - avril 2021 Retour au numéro
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