Developing a multivariable risk prediction model to predict prolonged viral clearance in patients with COVID-19 - 02/04/21

Doi : 10.1016/j.jinf.2020.12.026

Ying Liu ^a,^b,^c,^{^{1
These authors contributed equally to this work.}}, Min Li ^a,^d,^{^{1
These authors contributed equally to this work.}}, Dan Liu ^a,^{^{1
These authors contributed equally to this work.}}, Jian Fei Luo ^e,^{^{1
These authors contributed equally to this work.}}, Nian Li ^f, Xuan Zhang ^a, Xiao Ju Tang ^b, Xin Zhang ^a,^b,^c, Jia Liu ^a,^b, Ji Wang ^a,^b, Ting Wang ^a,^b, Yong Zao Zhou ^a,^b, Wen Xin Luo ^a,^b, Zong An Liang ^a,^⁎ , Feng Ming Luo ^a,^b,^⁎ , Wei Min Li ^a,^⁎ , Gang Wang ^a,^b,^⁎
^{^a} Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China
^b Laboratory of Pulmonary Immunology and inflammation, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, PR China
^c Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China
^d Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650032, PR China
^e Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430022, Hubei, PR China
^f Department of Medical Affairs, West China Hospital, Sichuan University, Chengdu 610041, PR China

^⁎Corresponding authors.^⁎⁎Corresponding authors at: Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.Department of Respiratory and Critical Care MedicineClinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengduSichuan610041PR China

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Highlights

•	A multivariable risk prediction model was developed to predict a patient's risk of prolonged SARS-CoV-2 RNA clearance.
•	Six independent risk factors for prolonged duration of viral clearance were found.
•	Estimating these risk factors could promote individual precision therapy and optimizing the use of medical resources.

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Keywords : COVID-19, SARS-CoV-2, Viral clearance, Prediction model

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Vol 82 - N° 4

P. e20-e22 - avril 2021 Retour au numéro

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