Genetic Influence on Choroidal Volume - 14/04/21
Abstract |
Purpose |
To evaluate the degree of genetic influence on macular choroidal volume.
Design |
A cross-sectional twin and family study.
Methods |
In total, 353 Korean adults with healthy eyes from 78 households with 2 or more family members were included in the study. Macular choroidal volume was measured using spectral-domain optical coherence tomography with enhanced depth imaging at 9 macular subfields defined by the ETDRS. Demographics and clinical characteristics were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. The associations of these factors with macular choroidal volume were assessed using univariate and subsequent multivariate regression analyses while accounting for family structure. The heritability estimates of macular choroidal volume in total and at each of the 9 macular subfields were calculated after adjusting the covariates.
Results |
Patients who were younger, male, and had a shorter axial length showed associations with greater choroidal volume (P < .001 for all 3 independent variables). The covariates-adjusted heritability (±standard error) of the total macular choroidal volume was 0.76 ± 0.06, and the heritabilities of choroidal volume at each subfield ranged from 0.55 ± 0.09 (inner temporal subfield) to 0.77 ± 0.08 (inner superior subfield).
Conclusion |
The macular choroidal volume is highly heritable.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Macular choroidal volume is highly heritable with an estimated heritability of 0.76. |
Plan
| S. Hwang and M. Kang are co–first authors of this study. |
|
| Supplemental Material available at AJO.com. |
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| D-I. Ham and M. Kong are co-corresponding authors of this study. |
Vol 224
P. 143-149 - avril 2021 Retour au numéro
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