The glymphatic system hypothesis is associated with the circulation of cerebrospinal fluid (CSF) in the skull and interstitial fluid (ISF) in the brain. There are several imaging techniques to visualize the dynamics of CSF and ISF. Magnetic resonance imaging (MRI) is one of the promising modalities for glymphatic imaging and diffusion MRI is expected imaging tool. Several disorders are associated with glymphatic dysfunction or impairment in the dynamics of CSF or ISF. The Central Nervous System interstitial fluidopathy concept has been proposed to encompass diseases with pathologies that are predominantly associated with abnormal ISF/CSF dynamics.