Innate lymphoid cell development - 05/05/21
Abstract |
Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and group 3 ILC3, on the basis of their similar effector programs to T cells. The development of ILCs from lymphoid progenitors in adult mouse bone marrow has been studied in detail, and multiple ILC progenitors have been characterized. ILCs are mostly tissue-resident cells that develop in the perinatal period. More recently, ILC progenitors have also been identified in peripheral tissues. In this review, we discuss the stepwise transcription factor–directed differentiation of mouse ILC progenitors into mature ILCs, the critical time windows in ILC development, and the contribution of bone marrow versus tissue ILC progenitors to the pool of mature ILCs in tissues.
Le texte complet de cet article est disponible en PDF.Key words : Innate lymphoid cells, ILCs, development, transcription factors, progenitors
Abbreviations used : Ahr, BM, BPD, CHILP, CLP, DC, EILP, Eomes, ETP, HSC, GATA-3, ILC1, ILC2, ILC2P, ILC3, ILCP, LMPP, LTi, NK, NKP, PLZF, RAG, ROR, TRAIL, αLP
Plan
| This work was supported by grants from the Canadian Institute of Health Research. |
|
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
|
| Terms in boldface and italics are detailed in the glossary on page 1550. |
Vol 147 - N° 5
P. 1549-1560 - mai 2021 Retour au numéro
Article précédent
- Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s
- Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines
- Susan Waserman, Heather Cruickshank, Kyla J. Hildebrand, Douglas Mack, Laura Bantock, Theresa Bingemann, Derek K. Chu, Carlos Cuello-Garcia, Motohiro Ebisawa, David Fahmy, David M. Fleischer, Lisa Galloway, Greg Gartrell, Matthew Greenhawt, Nicola Hamilton, Jonathan Hourihane, Michael Langlois, Richard Loh, Antonella Muraro, Lana Rosenfield, Sally Schoessler, Mimi L.K. Tang, Brenda Weitzner, Julie Wang, Jan L. Brozek
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?