High or low temperature extraction, which is more conducive to Triphala against chronic pharyngitis? - 17/06/21
, Xue Han b, 1 , Xuan Deng a , Zhenfeng Wu c , Haozhou Huang a , Ming Qiu a , Jiao Song a , Xichuan Wei a , Dingkung Zhang a , Yu Wang d , Sanhu Fan e , Junzhi Lin f, ⁎ , Li Han a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 6 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objective |
Explore the effects of high-temperature reflux extraction and low-temperature decompressing inner ebullition on Triphala's chemical composition and anti-chronic pharyngitis activity.
Methods |
The network pharmacology was used to analyze the material basis, targets and pathways of Triphala for chronic pharyngitis. HPLC were used to compare the fingerprint profile and content of components between the two extracts. The antioxidant and anti-chronic pharyngitis activities of the two extracts were compared by DPPH assay and ammonia induced chronic pharyngitis model in rats.
Results |
The network pharmacology results showed that the active ingredients of Triphala for chronic pharyngitis are epigallocatechin-3-gallate, (+)-catechin, epicatechin, epicatechin gallate, (+)-gallocatechin, quercetin, luteolin, leucodelphinidin and other flavonoids; phenolic acids such as gallic acid and ellagic acid; alkaloids such as ellipticine, cheilanthifoline; hydrolyzed tannins such as corilagin and chebulic acid. The high-temperature reflux extract and the low-temperature decompressing inner ebullition extract have extremely significant differences in the fingerprint profile. Among them, the content of gallic acid, ellagic acid, chebulic acid, catechin, epicatechin, corilagin, quercetin, and epicatechin gallate in the reflux extract is 1.1–5.3 times as much as decompressing inner ebullition extract. The free radical scavenging ability of reflux extract is significantly stronger than that of decompression extract (p < 0.01), and it has a repairing effect on pharyngeal mucosal damage (reducing keratinization or hyperplasia of mucosal epithelium, reducing inflammatory cell infiltration and bleeding), and reducing IL-1β (P＜0.05), IL-6 (p＜0.05), TNF-α overexpression ability is stronger than the decompressing inner ebullition extract.
Conclusions |
gallic acid, ellagic acid, chebulic acid, catechin, epicatechin, corilagin and epicatechin gallate are the basic aglycones or oligomers of tannin. High temperature reflux extraction can significantly promote the occurrence of the hydrolysis of tannins and significantly increases the content of these components.Therefore, its anti-chronic pharyngitis activity is enhanced. It is suggested that high temperature reflux extraction should be used in the treatment of chronic pharyngitis.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Chronic pharyngitis (CP) is a prevalent health problem. |
• | Triphala has significant therapeutic effect on chronic pharyngitis. |
• | The extraction temperature has influence on the anti-chronic pharyngitis activity of Triphala. |
• | High temperature promotes the hydrolysis of hydrolyzed tannins in Triphala to generate active compounds. |
Abbreviations : CP, WHO, GI, RE, DIE, SD, TCMSP, OB, DL, ADME, BATMAN-TCM, SEA, TTD, CTD, HPO, ROS, IC50, GO, BP, MF, CC, IL6, TNF, AKT1, STAT3
Keywords : Triphala, Decompressing inner ebullition, Reflux extraction, Chronic pharyngitis
Plan
Vol 140
Article 111787- août 2021 Retour au numéro
Article précédent
- Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models
- Riham A. El-Shiekh, Dorria Hussein, Attia H. Atta, Samar M. Mounier, Mohamed R. Mousa, Essam Abdel-Sattar
- GABAB receptors blockage modulates somatic and aversive manifestations induced by nicotine withdrawal
- AP Varani, VT Pedrón, AJ Aon, EM Canero, GN Balerio
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?