The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients - 19/06/21

Doi : 10.1016/j.jinf.2021.04.023

Elisa Teyssou ^a,^⁎ , Cathia Soulie ^a,^⁎, Benoit Visseaux ^b, Sidonie Lambert-Niclot ^c, Valentine Ferre ^b, Stéphane Marot ^a, Aude Jary ^a, Sophie Sayon ^a, Karen Zafilaza ^a, Valentin Leducq ^a, Aurélie Schnuriger ^d, Basma Abdi ^a, Marc Wirden ^a, Nadhira Houhou-Fidouh ^b, Charlotte Charpentier ^b, Laurence Morand-Joubert ^c, Sonia Burrel ^a, Diane Descamps ^b, Vincent Calvez ^a, Anne Geneviève Marcelin ^a
^a Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, laboratoire de virologie, F-75013 Paris, France
^b Service de Virologie, Université de Paris INSERM, IAME, UMR 1137, AP-HP, Hôpital Bichat-Claude Bernard, F-75018 Paris, France
^c Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Universitaire Saint Antoine, laboratoire de virologie, F-75012 Paris, France
^d AP-HP, Hôpital Universitaire Armand-Trousseau, laboratoire de virologie, F-75012, Paris, France.

^⁎Corresponding author at: Department of Virology, Pitié-Salpêtrière Hospital, 83 Boulevard de, l'Hôpital, 75013 Paris, France.Department of Virology, Pitié-Salpêtrière Hospital83 Boulevard de, l'HôpitalParis75013France

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Highlights

•	Viral load in COVID-19 patient nasopharyngeal samples was different between variants.
•	The 501Y.V2 variant had a viral load 2 times higher than the historical variants
•	The 501Y.V2 variant had a viral load slightly lower than the 501Y.V1
•	The 501Y.V1 variant had a viral load 3-10 times higher than the historical variants

A spread of the 501Y.V2 (lineage B1.351) into the world and specially in the United Kingdom (UK) has been reported by Tang et al.^{1Tang Julian W. Introduction of the South African SARS-CoV-2 variant 501Y.V2 into the UK J Infect 2021 ; 3

Cliquez ici pour aller à la section Références}. As the 501Y.V1 (lineage B1.1.7), which emerged in the UK^{2covid19-33-en-210112.pdf n.d.

Cliquez ici pour aller à la section Références}, this variant notably present specific genetic patterns in the gene encoding the Spike protein (S). It was estimated that the 501Y.V1 presented a greater infectivity (up to 70%) and recent studies suggested a higher viral load (VL) for the 501Y.V1 as compared to the historical SARS-CoV-2^3,4. Currently, few data are available on the VL of the 501Y.V2. In France, these two variants are actively spreading into the population since late January and currently representing up to 70% of the new positive cases for the 501Y.V1 and 6% for the 501Y.V2 in Paris area.

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Keywords : SARS-CoV-2, Variants, 501Y.V1, 501Y.V2, Viral load

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Vol 83 - N° 1

P. 119-145 - juillet 2021 Retour au numéro

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The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients - 19/06/21

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