Neural Correlates of Positive Emotion Processing That Distinguish Healthy Youths at Familial Risk for Bipolar Versus Major Depressive Disorder - 23/06/21
Abstract |
Objective |
Familial risk for bipolar disorder (BD) or major depressive disorder (MDD) may lead to differential emotion processing signatures, resulting in unique neural vulnerability.
Method |
Healthy offspring of a parent with BD (n = 29, “BD-risk”) or MDD (n = 44, “MDD-risk”) and healthy control youths without any personal or family psychopathology (n = 28, “HC”) aged 8 to 17 years (13.64 ± 2.59 years) completed an implicit emotion-perception functional magnetic resonance imaging task. Whole-brain voxelwise and psychophysiological interaction analyses examined neural differences in activation and connectivity during emotion processing. Regression modeling tested for neural associations with behavioral strengths and difficulties and conversion to psychopathology at follow-up (3.71 ± 1.91 years).
Results |
BD-risk youth showed significantly reduced bilateral putamen activation, and decreased connectivity between the left putamen and the left ventral anterior cingulate cortex (vACC) and the right posterior cingulate cortex (PCC) during positive-valence emotion processing compared to MDD-risk and HC (Z >2.3; p <.001). Decreased left putamen−right PCC connectivity correlated with subsequent peer problems in BD-risk (β = −2.90; p <.05) and MDD-risk (β = −3.64; p < .05) groups. Decreased left (β = −0.09; p < .05) and right putamen activation (β = −0.07; p = .04) were associated with conversion to a mood or anxiety disorder in BD-risk youths. Decreased left putamen−right PCC connectivity was associated with a higher risk of conversion in BD-risk (HR = 8.28 , p < .01) and MDD-risk (HR = 2.31, p = .02) groups.
Conclusion |
Reduced putamen activation and connectivity during positive emotion processing appear to distinguish BD-risk youths from MDD-risk and HC youths, and may represent a marker of vulnerability.
Le texte complet de cet article est disponible en PDF.Key words : risk and resilience, bipolar disorder, major depressive disorder, emotion processing, fMRI
Plan
| This research was supported by the National Institute of Mental Health (NIMH; grant K23MH085919) and The Stanford Maternal Child Health Research Institute to M.K.S., the Ford Foundation Predoctoral Fellowship, the National Science Foundation Graduate Research Fellowship Program, and Stanford’s DARE Fellowship to A.F.N., and NIMH (grant T32MH019938) to A.S.F. The funding sources had no role in the design or conduct of the study: collection, management, analysis and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. |
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| Jane Kim, PhD, of the Stanford University Department of Psychiatry, served as the statistical expert for this research. |
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| Author Contributions |
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| Conceptualization: Nimarko, Fischer, Hagan, Singh |
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| Data curation: Nimarko, Singh |
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| Formal analysis: Nimarko, Young |
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| Funding acquisition: Singh |
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| Investigation: Nimarko, Fischer, Hagan, Gorelik, Lu, Singh |
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| Methodology: Nimarko, Hagan, Lu, Singh |
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| Project administration: Nimarko, Fischer, Singh |
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| Resources: Nimarko, Hagan, Singh |
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| Supervision: Singh |
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| Visualization: Nimarko, Gorelik |
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| Writing – original draft: Nimarko |
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| Writing – review and editing: Nimarko, Fischer, Hagan, Gorelik, Lu, Young, Singh |
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| ORCID |
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| Akua F. Nimarko, BS: 0000-0003-2170-9097 |
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| Adina S. Fischer, MD, PhD: 0000-0001-5810-8944 |
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| Kelsey E. Hagan, PhD: 0000-0001-5723-3591 |
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| Aaron J. Gorelik, BS: 0000-0002-2589-1220 |
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| Yvonne Lu, BS: 0000-0003-4574-820X |
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| Caroline J. Young, MS: 0000-0001-8387-2151 |
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| Manpreet K. Singh, MD, MS: 0000-0002-4373-3293 |
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| Disclosure: Dr. Singh has received research support from NIMH, the National Institute on Aging, the Patient-Centered Outcomes Research Institute, Johnson and Johnson, Allergan, and the Brain and Behavior Research Foundation. She has served on the advisory board for Sunovion and as a consultant for X, the moonshot factory (Alphabet Inc.) and Limbix and has received royalties from American Psychiatric Association Publishing. Dr. Fischer has received research support from The Klingenstein Third Generation Foundation. Dr. Hagan, Ms. Nimarko, Mr. Gorelik, Mss. Lu and Young have reported no biomedical financial interests or potential conflicts of interest. |
Vol 60 - N° 7
P. 887-901 - juillet 2021 Retour au numéro
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