Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder - 22/07/21
Doi : 10.1016/S1474-4422(21)00176-9
Mitchell G Miglis, MD a, ⁎ 
, Charles H Adler, ProfMD b, Elena Antelmi, MD c, Dario Arnaldi, MD d, e, Luca Baldelli, MD f, Bradley F Boeve, ProfMD g, Matteo Cesari, PhD h, Irene Dall’Antonia, MD i, Nico J Diederich, ProfMD j, Kathrin Doppler, MD k, Petr Dušek, MD i, Raffaele Ferri, ProfMD l, Jean-François Gagnon, ProfPhD m, Ziv Gan-Or, MD n, Wiebke Hermann, MD o, p, Birgit Högl, ProfMD h, Michele T Hu, ProfMD q, Alex Iranzo, MD r, Annette Janzen, MD s, Anastasia Kuzkina, MD k, Jee-Young Lee, MD t, Klaus L Leenders, ProfMD u, Simon J G Lewis, ProfMD v, Claudio Liguori, MD w, Jun Liu, MD x, Christine Lo, MD q, Kaylena A Ehgoetz Martens, PhD y, Jiri Nepozitek, MD i, Giuseppe Plazzi, ProfMD z, aa, Federica Provini, ProfMD f, z, ab, Monica Puligheddu, MD ac, Michal Rolinski, MD ad, Jan Rusz, PhD ae, Ambra Stefani, MD h, Rebekah L S Summers, PhD af, Dallah Yoo, MD ag, Jennifer Zitser, MD ah, ai, Wolfgang H Oertel, ProfMD s, aj
, Charles H Adler, ProfMD b, Elena Antelmi, MD c, Dario Arnaldi, MD d, e, Luca Baldelli, MD f, Bradley F Boeve, ProfMD g, Matteo Cesari, PhD h, Irene Dall’Antonia, MD i, Nico J Diederich, ProfMD j, Kathrin Doppler, MD k, Petr Dušek, MD i, Raffaele Ferri, ProfMD l, Jean-François Gagnon, ProfPhD m, Ziv Gan-Or, MD n, Wiebke Hermann, MD o, p, Birgit Högl, ProfMD h, Michele T Hu, ProfMD q, Alex Iranzo, MD r, Annette Janzen, MD s, Anastasia Kuzkina, MD k, Jee-Young Lee, MD t, Klaus L Leenders, ProfMD u, Simon J G Lewis, ProfMD v, Claudio Liguori, MD w, Jun Liu, MD x, Christine Lo, MD q, Kaylena A Ehgoetz Martens, PhD y, Jiri Nepozitek, MD i, Giuseppe Plazzi, ProfMD z, aa, Federica Provini, ProfMD f, z, ab, Monica Puligheddu, MD ac, Michal Rolinski, MD ad, Jan Rusz, PhD ae, Ambra Stefani, MD h, Rebekah L S Summers, PhD af, Dallah Yoo, MD ag, Jennifer Zitser, MD ah, ai, Wolfgang H Oertel, ProfMD s, aj a Department of Neurology and Neurological Sciences and Department of Psychiatry and Behavioral Science, Stanford University, Palo Alto, CA, USA
b Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ, USA
c Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
d Clinical Neurology, DINOGMI, University of Genoa, Genoa, Italy
e IRCCS Ospedale Policlinico San Martino, Genoa, Italy
f Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
g Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA
h Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
i Department of Neurology and Center of Clinical Neuroscience, Charles University First Faculty of Medicine, Prague, Czech Republic
j Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg
k Department of Neurology, University of Würzburg, Würzburg, Germany
l Oasi Research Institute IRCCS, Troina, Italy
m Centre for Advanced Research in Sleep Medicine, Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal–Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada
n The Neuro-Montreal Neurological Institute-Hospital, Department of Neurology and Neurosurgery, and Department of Human Genetics, McGill University, Montreal, QC, Canada
o Department of Neurology, University of Rostock, Rostock, Germany
p German Center for Neurodegenerative Diseases (DZNE), Research Site Rostock, Rostock, Germany
q Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
r Sleep Disorders Center, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, Barcelona, Spain
s Department of Neurology and Section on Clinical Neuroscience, Philipps University Marburg, Marburg, Germany
t Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea
u Department of Nuclear Medicine and Biomedical Imaging, University Medical Center Groningen, Groningen, Netherlands
v ForeFront Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia
w Sleep Medicine Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
x Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
y Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada
z IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
aa Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
ab UOC Clinica Neurologica Rete Metropolitana NEUROMET, Bellaria Hospital, Bologna, Italy
ac Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy
ad Institute of Clinical Neurosciences, University of Bristol, Bristol, UK
ae Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
af Department of Neurology, University of Minnesota, Minneapolis, MN, USA
ag Department of Neurology, Kyung Hee University Hospital, Seoul, South Korea
ah Department of Neurology and Neurological Sciences, University of California, San Francisco, CA, USA
ai Department of Neurology, Tel Aviv Sourasky Medical Center, Affiliate of Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
aj Institute for Neurogenomics, Helmholtz Center for Health and Environment, München-Neuherberg, Germany
*Correspondence to: Dr Mitchell G Miglis, Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USADepartment of Neurology and Neurological SciencesStanford UniversityPalo AltoCA94304USA
Summary |
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of α-synucleinopathy patients with isolated RBD might develop.
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Vol 20 - N° 8
P. 671-684 - août 2021 Retour au numéro
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