Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers - 24/07/21
Doi : 10.1016/j.jinf.2021.03.025
Marie Tré-Hardy a, b, c, ⁎ 
, Roberto Cupaiolo a, Emmanuelle Papleux d, Alain Wilmet a, Alexandra Horeanga e, Thomas Antoine-Moussiaux e, Andrea Della Vecchia e, Ingrid Beukinga a, Marc Vekemans e, Laurent Blairon a
, Roberto Cupaiolo a, Emmanuelle Papleux d, Alain Wilmet a, Alexandra Horeanga e, Thomas Antoine-Moussiaux e, Andrea Della Vecchia e, Ingrid Beukinga a, Marc Vekemans e, Laurent Blairon a a Department of Laboratory Medicine, Iris Hospitals South, Brussels, Belgium
b Faculty of Medicine, Université libre de bruxelles, Brussels, Belgium
c Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, Belgium
d Department of Pneumology, Iris Hospitals South, Brussels, Belgium
e Department of Infectious Diseases, Iris Hospitals South, Brussels, Belgium
⁎Corresponding author at: Department of Laboratory Medicine, Iris Hospitals South, Brussels, Belgium.Department of Laboratory MedicineIris Hospitals SouthBrusselsBelgium
Highlights |
• | A single dose of mRNA-1273 appears to be sufficient in the vast majority of seropositive individuals prior to vaccination. |
• | Previously infected workers experienced more frequent and severe common side effects after the first dose. |
• | The second dose induced greater overall reaction than the first one regardless of the serological status. |
Keywords : SARS-CoV-2, COVID-19, Immunogenicity, Reactogenicity, Safety, mRNA-1273 vaccine
Plan
© 2021
Publié par Elsevier Masson SAS.
Vol 83 - N° 2
P. 237-279 - août 2021 Retour au numéro
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