Erectile Dysfunction, Testosterone Levels and Disease Activity in Ankylosing Spondylitis Patients - 24/07/21
, LJ Heil Junior 1, Felipe Guzzo Fagundes 2, Bernardo Sobreiro 2, Ana P.B. Campos 1, Juliana Simioni 1, Thelma L. Skare 1ABSTRACT |
Objective |
To study erectile function in male patients with Ankylosing Spondylitis (AS) trying to correlate it with sexual hormonal profile and disease activity.
Methods |
We included 35 AS patients and 104 controls. Patients and controls answered the IIEF (International Index of Erectile Dysfunction) and had dosing of total testosterone, free testosterone (FT), bioavailable testosterone (BT), SHBG (serum hormone binding globulin), albumin and LH (luteinizing hormone). AS patients had epidemiological, clinical and treatment data obtained from the charts. AS disease activity was measured simultaneously with blood collection through Bath AS Disease Activity Index, ASDAS (AS Disease Activity Score) -ESR (using erythrocyte sedimentation rate) and ASDAS-CRP (using C reactive protein).
Results |
The IIEF results were worse in AS patients than controls (P = .02). Total testosterone and SHBG were higher in AS (with P = .01 and P <.0001 respectively). Between the 2 groups, no differences in LH, FT, BT levels (all with P = ns) were found. In AS patients, the IIEF results did not correlate with total testosterone, SHBG, LH, FT, and BT but a negative association was found with Bath AS Disease Activity Index (P = .001) and ASDAS-CRP (P = .02).
Conclusion |
AS patients had worst sexual performance than controls that was linked to disease activity but not to male sexual hormonal profile.
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| DECLARATIONS |
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| Funding: No fundings to declare. |
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| Conflicts of interest/Competing interests: All authors declare that there are not conflict of interest.. |
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| Disclosure: None. |
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| Ethics approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Committee of Ethics in Research (Comitê de Ética da Faculdade Evangélica Mackenzie de Medicina, Curitiba, PR, Brazil, number 2873147. |
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| Consent to participate All partipants signed a informed consent. |
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| Consent for publication: Yes. |
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| Transparency declaration. The authors affirm that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained. |
Vol 153
P. 210-214 - juillet 2021 Retour au numéro
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