and that reference citations are not used in the synopsis. A devastating complication of cardiac arrest is hypoxic-ischemic injury, which leads to neurologic dysfunction and subsequently high mortality. Post–cardiac arrest care is complex and requires a multimodal approach to manage hemodynamic instability as well as provide neuroprotection. Targeted temperature management is recommended by the American Heart Association as well as the International Liaison Committee on Resuscitation as a class 1 intervention for postarrest neuroprotection in patients who remain unresponsive after cardiac arrest.