Preterm Birth Is Associated With Depression From Childhood to Early Adulthood - 19/08/21
, Terhi Luntamo, MD, PhD a, Hanna-Maria Matinolli, PhD a, d, Roshan Chudal, MBBS, MPH, PhD a, Susanna Hinkka-Yli-Salomäki, PhLic a, Svetlana Filatova, PhD a, Keely Cheslack-Postava, PhD, MSPH e, Minna Sucksdorff, MD a, Mika Gissler, PhD a, d, f, Alan S. Brown, MD, MPH c, Liisa Lehtonen, MD, PhD a, bAbstract |
Objective |
There have been inconsistent findings on the associations among prematurity, poor fetal growth, and depression. We examined the associations among gestational age, poor fetal growth, and depression in individuals aged 5 to 25 years.
Method |
We identified 37,682 case subjects based on International Classification of Diseases, Ninth Revision code 2961 and International Classification of Diseases, Tenth Revision codes F32.0-F32.9 and F33.0-F33.9 from the Care Register for Health Care, and 148,795 matched controls from the Finnish Central Population Register. Conditional logistic regression examined the associations between gestational age by each gestational week, poor fetal growth, and depression. The associations were adjusted for parental age and psychopathology, paternal immigrant status, maternal substance abuse, depression, number of previous births, marital status, socio-economic status, smoking during pregnancy, and the infant’s birthplace.
Results |
In the adjusted models, increased risk of depression was found in children born ≤25 weeks (adjusted odds ratio [aOR] 1.89, 95% CI 1.08–3.31), at 26 weeks (aOR 2.62, 95% CI 1.49–4.61), at 27 weeks (aOR 1.93, 95% CI 1.05–3.53), and ≥42 weeks (aOR 1.11, 95% CI 1.05–1.19). In girls, extremely preterm birth was associated with depression diagnosed at 5 to 12 years (aOR 2.70, 95% CI 1.83–3.98) and 13 to 18 years (aOR 2.97, 95% CI 1.84–4.78). In boys, postterm birth (≥42 weeks) was associated with depression diagnosed at 19 to 25 years (aOR 1.28, 95% CI 1.07–1.54). Poor fetal growth was associated with an increased risk of depression in full-term infants (aOR 1.06, 95% CI 1.03–1.10) and postterm infants (aOR 1.24, 95% CI 1.08–1.43).
Conclusion |
Preterm birth before 28 weeks of gestation appeared to play a role in the development of childhood depression. Smaller effects were also seen in postterm births, especially in boys.
Le texte complet de cet article est disponible en PDF.Key Words : fetal growth, SGA, prematurity, epidemiology, mental disorders
Plan
| This research was supported by INVEST Research Flagship, APEX Research Consortium, and the Finnish Psychiatric Birth Cohort Consortium (PSYCOHORTS). Ms. Upadhyaya and Dr. Sucksdorff have received funding from the University of Turku Graduate School. Dr. Sourander has received funding from the Academy of Finland Flagship Programme (decision number 320162), the Strategic Research Council at the Academy of Finland (decision number 303581), and the Academy of Finland Health from Cohorts and Biobanks Programme (decision number 308552). Dr. Sucksdorff has received funding from the Pediatric Research Foundation, the Finnish Medical Foundation, and the Finnish Brain Foundation. The funders played no role in any aspect of the study or manuscript. |
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| Ms. Hinkka-Yli-Salomäki served as the statistical expert for this research. |
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| Author Contributions |
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| Conceptualization: Upadhyaya, Sourander |
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| Data curation: Upadhyaya, Sourander, Filatova, Cheslack-Postava, Sucksdorff, Gissler, Brown, Lehtonen |
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| Formal analysis: Hinkka-Yli-Salomäki |
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| Funding acquisition: Upadhyaya, Sourander, Sucksdorff |
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| Investigation: Upadhyaya, Sourander, Luntamo, Chudal, Hinkka-Yli-Salomäki, Filatova, Cheslack-Postava, Brown, Lehtonen |
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| Methodology: Upadhyaya, Sourander, Matinolli, Chudal, Hinkka-Yli-Salomäki, Cheslack-Postava, Sucksdorff, Gissler, Brown, Lehtonen |
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| Project administration: Sourander, Luntamo, Matinolli, Filatova, Sucksdorff |
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| Resources: Luntamo, Matinolli, Filatova, Cheslack-Postava, Sucksdorff, Gissler |
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| Supervision: Sourander, Chudal, Lehtonen |
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| Validation: Chudal |
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| Visualization: Sourander, Gissler, Brown, Lehtonen |
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| Writing – original draft: Upadhyaya |
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| Writing – review and editing: Upadhyaya, Sourander, Luntamo, Matinolli, Chudal, Hinkka-Yli-Salomäki, Filatova, Cheslack-Postava, Sucksdorff, Gissler, Brown, Lehtonen |
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| Disclosure: Prof. Sourander, Drs. Luntamo, Matinolli, Chudal, Filatova, Cheslack-Postava, Sucksdorff, Gissler, Profs. Brown and Lehtonen, and Mss. Upadhyaya and Hinkka-Yli-Salomäki have reported no biomedical financial interests or potential conflicts of interest. |
Vol 60 - N° 9
P. 1127-1136 - septembre 2021 Retour au numéro
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