Pharmacodynamic substances in Salvia miltiorrhiza for prevention and treatment of hyperlipidemia and coronary heart disease based on lipidomics technology and network pharmacology analysis - 03/09/21
, Yubo Li b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
In this study, untargeted lipidomics based on UPLC-Q/TOF-MS, network pharmacology and atomic force microscopy were used to explore the common biomarkers of hyperlipidemia and coronary heart disease, the therapeutic mechanism of the main components of Salvia miltiorrhiza as well as the action mechanism of key lipids. Firstly, the serum samples of 30 healthy people, 30 patients with coronary heart disease and 30 patients with hyperlipidemia were analyzed by using lipidomics technology to obtain biomarkers which can be used to link hyperlipidemia and coronary heart disease and to find potential targets; then, the key components and core targets of Salvia miltiorrhiza intervention in hyperlipidemia and coronary heart disease were analyzed by network pharmacology, the results were verified by atomic force microscopy. It showed that SMS2 might be the key target. And through network pharmacology and atomic force microscope analysis, it can be inferred that salvianolic acid A can combine with SMS2 to play a therapeutic role.
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Highlights |
• | SMS2 is speculated to be a potential target by lipidomics. |
• | Salvianolic acid A is supposed to be the main component in the treatment of hyperlipidemia and CHD. |
• | Atomic force microscope verified that salvia miltiorrhiza A could effectively bind with SMS2. |
Abbreviations : W. H. O., CHD, HL, UPLC-Q/TOF-MS, TCMSP, AFM, ACC/AHA, PCI, CABG, ESI, PCA, PLS-DA, OPLS-DA, VIP, HMDB, OB, DL, SMS2, KEGG, BP, GO, PBS, RSD, TC, LDL, HDL-C, LDL-C, APOE, PLA2, LDLR, VEGF, MAPK, PE, PC, LysoPC, OXLDL, LA, AA, COX, LOX, CYP450, PGHS, eNOS, SMS, LRP6, TLR4, IL-6
Keywords : Coronary heart disease, Hyperlipidemia, Lipidomics, Network pharmacology, Effective components
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Vol 141
Article 111846- septembre 2021 Retour au numéro
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