Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm - 03/09/21

Doi : 10.1016/j.pediatrneurol.2021.07.001

Karoliina Uusitalo, MD ^a,^b,^⁎ , Leena Haataja, MD, PhD ^c, Virva Saunavaara, PhD ^d,^e, Annika Lind, PhD ^f,^g, Victor Vorobyev, PhD ^b,^h, Joni Tilli, BM ^a, Riitta Parkkola, MD, PhD ^b,^h,^{^{∗∗
Equal contribution.}}, Sirkku Setänen, MD, PhD ^a,^b,^{^{∗∗
Equal contribution.}}
on behalf of the
PIPARI Study Group
Mikael Ekblad, MD, PhD, Satu Ekblad, RN, Eeva Ekholm, MD, PhD, Linda Grönroos, MD, Leena Haataja, MD, PhD, Mira Huhtala, MD, PhD, Jere Jaakkola, MD, Eveliina Joensuu, MA, Pentti Kero, MD, PhD, Riikka Korja, PhD, Katri Lahti, MD, Helena Lapinleimu, MD, PhD, Liisa Lehtonen, MD, PhD, Tuomo Lehtonen, MD, Marika Leppänen, MD, PhD, Annika Lind, PhD, Jaakko Matomäki, MSc, Jonna Maunu, MD, PhD, Petriina Munck, PhD, Laura Määttänen, MD, Pekka Niemi, PhD, Anna Nyman, PhD, Pertti Palo, MD, PhD, Riitta Parkkola, MD, PhD, Liisi Ripatti, MD, PhD, Päivi Rautava, MD, PhD, Katriina Saarinen : Physiotherapist, Tiina Saarinen, MD, Virva Saunavaara, PhD, Sirkku Setänen, MD, PhD, Matti Sillanpää, MD, PhD, Suvi Stolt, PhD, Päivi Tuomikoski-Koiranen, RN, Timo Tuovinen, BA, Karoliina Uusitalo, MD, Anniina Väliaho, MA, Milla Ylijoki, MD, PhD

^a Department of Pediatric Neurology, University of Turku, Turku, Finland
^b Turku University Hospital, Turku, Finland
^c University of Helsinki and Helsinki University Hospital, Children's Hospital, and Pediatric Research Center, Helsinki, Finland
^d Division of Medical Imaging, Department of Medical Physics, Turku University Hospital, Turku, Finland
^e Turku PET Centre, Turku University Hospital, Turku, Finland
^f Attentio Ltd, Turku, Finland
^g Department of Psychology, Åbo Akademi University, Turku, Finland
^h Department of Radiology, University of Turku, Turku, Finland

^∗Communications should be addressed to: Uusitalo; Department of Pediatric Neurology; Turku University Hospital; Kiinamyllynkatu 5-8; 20520 Turku, Finland.Department of Pediatric NeurologyTurku University HospitalKiinamyllynkatu 5-8Turku20520Finland

Abstract

Background

Fine motor and coordination problems are frequently reported among adolescents born preterm. We aimed to assess performance in hand coordination tasks and to compare concurrent brain activation between adolescents born very preterm and at term at 13 years.

Methods

A total of 34 right-handed adolescents born very preterm (gestational age less than 32 weeks/birth weight ≤1500 grams) and 37 controls born at term during 2003 to 2006 in Turku University Hospital, Finland, were recruited. At 13 years, finger opposition and diadochokinesis were assessed, and brain functional magnetic resonance imaging data were acquired while the adolescents performed unimanual hand coordination tasks in response to visual cue.

Results

Adolescents born very preterm performed similar to controls in hand coordination tasks. The very preterm group evoked greater brain activation than the controls in the right precentral gyrus and in the right postcentral gyrus during left-hand finger opposition and in the right postcentral gyrus during left-hand diadochokinesis. Within the very preterm group, lower gestational age was associated with reduced activation in the left superior parietal lobule during right-hand diadochokinesis. Regarding left-hand tasks, lower gestational age was associated with stronger activation in the right cerebellar lobule V and left cerebellar lobule VI during finger opposition and stronger activation in the right superior parietal lobule during diadochokinesis.

Conclusions

Very preterm birth affected hand coordination-related brain activation. Most of the effects were found for nondominant hand. Clinical performance during the hand coordination tasks was similar in adolescents born very preterm and controls.

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Keywords : Fine motor, fMRI, Follow-up, Prematurity

Plan

Introduction

Methods and statistics

Participants

Brain MRI at term age

Hand coordination tasks

Structural MRI

Functional MRI

Building of a composite region of interest for analysis

Functional MRI data processing and selection of participants

Statistical analysis of fMRI data

Results

Discussion

	Declarations of interest: None.
	Funding sources: The phases of this study were funded with grants from Finska Läkaresällskapet, Suomen Lääketieteen Säätiö and Lastentautien Tutkimussäätiö. Unfortunately, we did not use specific Grant IDs. These research funders are also listed in the Rights and Access form.

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Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm - 03/09/21

Abstract

Background

Methods

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