Examining Associations Between Dietary Inflammatory Index in Pregnancy, Pro-inflammatory Cytokine and Chemokine Levels at Birth, and Offspring Asthma and/or Wheeze by Age 4 Years - 20/09/21
, Michaela P. Palumbo, MS 2, Katherine A. Sauder, PhD 3, 4, Deborah H. Glueck, PhD 5, 6, Anne P. Starling, PhD 7, 8, Brandy M. Ringham, PhD 6, Liam O’Mahony, PhD 9, Brianna F. Moore, PhD 6, Ivana V. Yang, PhD 10, Dana Dabelea, MD, PhD 11Abstract |
Background |
Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze.
Objective |
The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-6, IL-10, tumor necrosis factor-α) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years.
Design |
The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring.
Participants and setting |
This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years.
Main outcome measures |
Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records.
Statistical analyses performed |
Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma.
Results |
Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels.
Conclusions |
The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level.
Le texte complet de cet article est disponible en PDF.Keywords : Dietary inflammatory index, Asthma, Cytokines
Plan
| Supplementary materials: The Figure and Table 3 are available at www.jandonline.org. |
|
| STATEMENT OF POTENTIAL CONFLICT OF INTEREST C. Venter provided educational material or reviewed educational materials for Abbott Laboratories, Danone, and Reckitt Benckiser.L. O’Mahony has provided consultancy with Alimentary Health, research grant from GlaxoSmithKline. The other authors declare no conflicts of interest. |
|
| FUNDING/SUPPORT This work was supported by the National Institutes of Health, Grant Nos.: R01 DK076648/DK/NIDDK NIH HHS/United States, R01 GM121081/GM/NIGMS NIH HHS/United States, UG3 OD023248/OD/NIH HHS/United States, UH3 OD023248/OD/NIH HHS/United States, R25GM111901-S1, R25GM111901, and R00ES025817. |
|
| AUTHOR CONTRIBUTIONS C. Venter drafted the paper. M. P. Palumbo performed the data analysis and drafted the methods and results section, with D. H. Glueck and B. M. Ringham. B. F. Moore calculated the DII scores. K. A. Sauder and D. Dabelea (Principal Investigator of the Healthy Start study) provided data from the Healthy Start study and guided the project. L. O’Mahony and I. V. Yang assisted with the interpretation of asthma and immunology data. A. Starling assisted with interpretation of statistical analysis. All authors read the paper and contributed to interpretation of the data. |
Vol 121 - N° 10
P. 2003 - octobre 2021 Retour au numéro
Article précédent
- Associations of Dairy Intake with Circulating Biomarkers of Inflammation, Insulin Response, and Dyslipidemia among Postmenopausal Women
- Ni Shi, Susan Olivo-Marston, Qi Jin, Desmond Aroke, Joshua J. Joseph, Steven K. Clinton, JoAnn E. Manson, Kathryn M. Rexrode, Yasmin Mossavar-Rahmani, Lesley Fels Tinker, Aladdin H. Shadyab, Rhonda S. Arthur, Linda G. Snetselaar, Linda Van Horn, Fred K. Tabung
- Relationships Among the Physical and Social Home Food Environments, Dietary Intake, and Diet Quality in Mothers and Children
- Samantha M. Rex, Amanda Kopetsky, Barry Bodt, Shannon M. Robson
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?