Severe asthma in Kuwait population: Phenotype-based approach - 19/10/21
, Jasmina Nurkic b , Yasmine Othman b , Edin Jusufovic c , Ahmed Maher b Abstract |
Background |
There is increasing recognition of marked phenotypic heterogeneity within severe asthma patients.
Methods |
Severe asthma patients on GINA step 4 or 5 treatment, followed up at Al-Rashed Allergy center Kuwait, were evaluated for: demographics (gender, age, age of asthma onset), comorbidities (allergic rhinitis (AR), chronic rhinosinusitis (CRS), chronic rhinosinusitis with nasal polyposis (CRSwNP), obesity), blood biomarkers (total serum Immunoglobulin E (IgE), peripheral eosinophils), and sensitization to inhalants allergens.
Results |
A total of 169 patients were candidates for biological treatment. Patients were divided in two groups based on level of total IgE as a “low” group with IgE<160 IU/ml (n = 55) and “high” group with IgE≥ 160 IU/ml (n = 114). Both groups were further divided in subgroups, “low” and “high”, based on absolute number of eosinophils (Eos) in peripheral blood with <300 cells/μl or ≥ 300 cells/μl. Only 10% of patients were in low IgE/low Eos while majority (46%) were in the high IgE/high Eos group. Mean age of patients was 44.1 year with domination of females (n = 123). Majority of patients were obese. AR, CRS and CRSwNP were more common in group with IgE ≥160 IU/ml, while CRS and CRSwNP in group with Eos ≥300 cells/μl.
Conclusion |
The majority of severe asthma patients in Kuwait are obese females with adult-onset asthma (>18 years of age) who were allergic with comorbid conditions including AR, CRS and CRSwNP, which correlates well with the level of Eos.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Assessment of blood biomarkers ie. sIgE and blood EOS can identify severe asthma patients eligible for biological treatment. |
• | Obese females with adult-onset asthma and atopy predominate among severe, uncontrolled asthma patients in Kuwait. |
• | Co-morbidities such as allergic rhinitis and chronic rhinosinusitis with or without NPs correlate with blood EOS levels. |
Keywords : Severe asthma, Phenotype, Allergic, Eosinophilic
Abbreviations : GINA, IgE, Eo, BMI, IL-5, IL-5r, sIgE, SPT, AR, CRS, CRSwNP, BAL, FeNO
Plan
Vol 187
Article 106586- octobre 2021 Retour au numéro
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