Measuring Sleep, Wakefulness, and Circadian Functions in Neurologic Disorders - 26/10/21

Doi : 10.1016/j.jsmc.2021.08.005

Markus H. Schmidt, MD, PhD ^a,^b,^⁎,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}} , Martijn P.J. Dekkers, MD, PhD ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Sébastien Baillieul, MD, PhD ^a,^c,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Jasmine Jendoubi, MSc ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Marie-Angela Wulf, MD, PhD ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Elena Wenz, MD ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Livia Fregolente, MD ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Albrecht Vorster, PhD ^a,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Oriella Gnarra, MSc ^a,^d,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}, Claudio L.A. Bassetti, MD ^a,^e,^{^{1
Present address: Schlaf-Wach-Epilepsie Zentrum (SWEZ), Universitätsklinik für Neurologie, Bern University Hospital, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.}}
^a Department of Neurology, Bern University Hospital (Inselspital) and University Bern, Switzerland
^b Ohio Sleep Medicine Institute, 4975 Bradenton Avenue, Dublin, OH 43017, USA
^c Univ. Grenoble Alpes, Inserm, U1300, CHU Grenoble Alpes, Service Universitaire de Pneumologie Physiologie, Grenoble 38000, France
^d Sensory-Motor System Lab, IRIS, ETH Zurich, Switzerland
^e Department of Neurology, University of Sechenow, Moscow, Russia

^∗Corresponding author. Inselspital, Universitätsklinik für Neurologie CH-3010 BernInselspitalUniversitätsklinik für NeurologieCH-3010 Bern

Résumé

Neurologic disorders impact the ability of the brain to regulate sleep, wake, and circadian functions, including state generation, components of state (such as rapid eye movement sleep muscle atonia, state transitions) and electroencephalographic microarchitecture. At its most extreme, extensive brain damage may even prevent differentiation of sleep stages from wakefulness (eg, status dissociatus). Given that comorbid sleep-wake-circadian disorders are common and can adversely impact the occurrence, evolution, and management of underlying neurologic conditions, new technologies for long-term monitoring of neurologic patients may potentially usher in new diagnostic strategies and optimization of clinical management.

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Keywords : Sleep, Wakefulness, Circadian, Stroke, Neurodegenerative disorders, Neuroimmunology, Polysomnography, Sleep architecture