Exposure to persistent organic pollutants and the risk of type 2 diabetes: a case-cohort study - 02/11/21
, Fanny Rancière c, d, 1, Rémy Slama e, f, Ronan Roussel g, h, i, Hannu Kiviranta j, Xavier Coumoul k, Beverley Balkau l, Jérémie Botton m, nthe D.E.S.I.R. Study Group
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Highlights |
• | Exposure to 22 persistent organic pollutants was studied in 753 people |
• | These 22 included polychlorinated biphenyls and organochlorine insecticides |
• | Associations with 9-year, incident type 2 diabetes were studied |
• | None of the compounds, nor combinations, was associated with type 2 diabetes risk |
• | We found no support for the hypothesis that persistent organic pollutants are independent risk factors for diabetes |
Abstract |
Aims |
To explore exposure to 22 persistent organic pollutants (POPs) and incident type 2 diabetes in a population-based, prospective cohort.
Methods |
This case-cohort study on 753 participants without type 2 diabetes at baseline, was followed-up over nine years, as part of the French D.E.S.I.R. cohort. We measured 22 POPs in fasting serum at baseline. The associations between baseline POP concentrations, pre-adjusted for lipids, BMI, age and sex, with incident type 2 diabetes, were assessed using Prentice-weighted Cox regression models (time scale: age), adjusted for traditional confounding factors. POPs were also modelled summed in functional groups: polychlorinated biphenyls (∑PCB) and organochlorines (∑OC) and also individually, after log-transformation, in adjusted Cox models.
Results |
There were 200 incident diabetes cases over nine years. Pre-adjusted POP concentrations were not related to diabetes risk for any of the 22 POPs examined. The fully-adjusted hazard ratios (HRs) per interquartile range of the pre-adjusted POPs, ranged from 0.87 (95% CI: 0.64,1.19) to 1.22 (0.93,1.59,). For dichlorodiphenyldichloroethylene (p, p'-DDE) and dichlorodiphenyltrichloroethane (p, p'-DDT), the HRs were 1.09 (0.83,1.43) and 0.89 (0.70,1.13), respectively. The HRs for PeCB, HCB, β-HCH, γ–HCH, oxychlordane, trans-nonachlor were 0.98 (0.85,1.13), 1.06 (0.84,1.33), 1.22 (0.93,1.59), 1.13 (0.89,1.42), 1.00 (0.76,1.31), 0.86 (0.66,1.13), respectively. HRs for ∑PCB, ∑OC and for individual log-transformed POPs did not differ significantly from one.
Conclusion |
We did not observe any relations between exposure to POPs and diabetes in this population-based cohort. These results do not support causal inferences reported in previous studies linking serum POP concentrations and diabetes risk.
Le texte complet de cet article est disponible en PDF.Keywords : Diabetes mellitus, Incidence, Organic pollutants, Organochlorine insecticides, Persistent, Pesticides, Polybrominated biphenyls
Plan
Vol 47 - N° 5
Article 101234- septembre 2021 Retour au numéro
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