Joining Forces : How to Coordinate Large, Multicenter Randomized Trials - 11/11/21

Doi : 10.1016/j.ccm.2021.08.011

Lance Roller, MS ^a, Lonny B. Yarmus, DO, MBA ^b, Robert J. Lentz, MD ^a,^c,^d,^⁎
^a Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, T-1218 MCN, Nashville, TN 37232-2650, USA
^b Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21287, USA
^c Department of Thoracic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South, T-1218 MCN, Nashville, TN 37232-2650, USA
^d Department of Veterans Affairs Medical Center, Nashville, TN, USA

^∗Corresponding author. Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, T-1218 MCN, Nashville, TN 37232-2650.Division of Allergy, Pulmonary, and Critical Care MedicineVanderbilt University Medical Center1161 21st Avenue South, T-1218 MCNNashvilleTN37232-2650

Résumé

This article details the pros, cons, challenges/pitfalls, and elements required for the successful conduct of multicenter randomized trials, with specific focus on trials related to pleural diseases. Several networks dedicated to the multicenter study of important pleural conditions have developed, yielding practice-changing studies in pleural disease. This review describes the importance of multicenter trials, major elements required for the conduct of such trials, and lessons learned from the ongoing development of the Interventional Pulmonary Outcomes Group, a consortium of interventional pulmonologists dedicated to advancing diagnostic and management strategies in pleural, pulmonary parenchymal, and airway disease by generating high-quality multicenter evidence.

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Keywords : Clinical trials, Randomized, Multicenter trial, Pleural disease, Research designs

Plan

Key points

Introduction

Discussion

The Case for High-Quality Research in Pleural Disease

Definition of a Multicenter Trial

Advantages of Multicenter Trials

Challenges of Multicenter Research

Elements of a Successful Multicenter Randomized Controlled Trial

Summary

Clinics care points

Financial/nonfinancial disclosures

Funding/role of sponsors

	Summary COI statement: No authors report any financial or nonfinancial conflicts of interest pertinent to this work.
	Funding information: Nonfunded work.
	Notification of prior publication/presentation: No aspect of this work has been previously published nor is under consideration by any other journals.