Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea - 15/11/21
Abstract |
Objective |
To evaluate structural and functional carotid changes and inflammatory profiles in children with obstructive sleep apnea (OSA) and healthy controls.
Study design |
Patients with OSA and matched controls (ages 5-13 years) were recruited. Proinflammatory cytokines and acute phase reactants were measured at 6:00 p.m. Common carotid artery measures were determined using ultrasound. Confirmatory factor analysis was used to determine subgroups of cytokines and their effects on carotid measures.
Results |
Ninety-six patients participated (53 healthy controls, 43 patients with OSA). OSA was associated with increased proinflammatory cytokines (cluster of differentiation-40 ligand [CD40-L], interleukin [IL]-6, and IL-8) and high sensitivity C-reactive protein (P < .05 for all). One cytokine subgroup (IL-6 and IL-8) was negatively associated with markers of carotid function, indicating reduced arterial distensibility and increased stiffness (P < .05 for 3 ultrasound measures); and tumor necrosis factor-α had an opposing effect on carotid function compared with this cytokine subgroup (P < .05 for 2 ultrasound measures). Linear regression demonstrated significant associations between and tumor necrosis factor- α and 2 measures of carotid function (P < .05 for each). Children with OSA did not have functional or structural carotid changes compared with controls.
Conclusion |
OSA was not directly associated with structural and functional carotid changes but was associated with upregulation of key proinflammatory cytokines (sCD40-L, IL-6, and IL-8). Together, IL-6 and IL-8 were associated with changes in carotid function. Longitudinal studies are needed to demonstrate that the inflammatory milieu observed in our population is a precursor of atherosclerosis in children.
Le texte complet de cet article est disponible en PDF.Keywords : carotid intima media thickness, obstructive sleep apnea syndrome, pediatric OSA, cardiovascular disease, inflammation
Abbreviations : AHI, BMI, BP, CFA, CIT, hs-CRP, IL, OSA, PM, PSG, PTT, sCD40-L, TNF
Plan
| Funded by NIHR01HL080670-01 (to R.A.), 8 UL 1 TR000077-04 (to R.A.), the American Society of Pediatric Otolaryngology (ASPO) Basic Research grant (to D.S.), the Triological Society Career Development Award (to D.S.), NIH5K08HL148551-02 (to D.S.), and the Cincinnati Children's Hospital Medical Center Procter Scholar Award (to D.S.). The study sponsors had no role in study design, the collection, analysis, and interpretation of data, the writing of the report, and the decision to submit the paper for publication. The authors declare no conflicts of interest. |
Vol 239
P. 168-174 - décembre 2021 Retour au numéro
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