Enhanced recovery after elective craniotomy: A randomized controlled trial - 27/11/21
Abstract |
Study objectives |
Enhanced recovery after surgery (ERAS) protocols have been proven to improve outcomes but have not been widely used in neurosurgery. The purpose of this study was to design a multidisciplinary enhanced recovery after elective craniotomy protocol and to evaluate its clinical efficacy and safety after implementation.
Design |
A prospective randomized controlled trial.
Setting |
The setting is at an operating room, a post-anesthesia care unit, and a hospital ward.
Patients |
This randomized controlled trial (RCT) prospectively analyzed 151 patients who underwent elective craniotomy between January 2019 and June 2020.
Interventions |
The neurosurgical ERAS group was cared for with evidence-based systematic optimization approaches, while the control group received routine care.
Measurements |
The primary outcomes were the postoperative length of stay (LOS) and hospitalization costs. The secondary outcomes included 30-day readmission rates, postoperative complications, postoperative pain scores, length of intensive care unit (ICU) stay, duration of the drainage tube, time to oral intake, time to ambulation, and postoperative functional recovery status.
Main results |
After ERAS protocol implementation, the median postoperative LOS (4 days to 3 days, difference [95% confidence interval, CI], 2 [1, 2], P < 0.0001) and hospitalization costs (6266 USD to 5880 USD, difference [95% CI], 427.0 [234.8 to 633.6], P < 0.0001) decreased. Compared to routine perioperative care, the ERAS protocol reduced the incidence of postoperative nausea and vomiting (PONV) (28.0% to 9.2%, adjusted odds ratio [OR] 0.3, 95% CI 0.1–0.7, P = 0.003), shortened urinary catheter removal time by 24 h (64.0% to 83.0%, adjusted OR 2.9, 95% CI 1.3–6.5, P = 0.031), improved ambulation on postoperative day 1 (POD 1) (30.7% to 75.0%, adjusted OR 7.5, 95% CI 3.6–15.8, P < 0.0001), shortened the time to oral intake (15 h to 13 h, difference [95% CI], 3 [1, 2, 3, 4], P < 0.001), and improved perioperative pain management.
Conclusions |
Implementation of an enhanced recovery after elective craniotomy protocol had significant benefits over conventional perioperative management. It was associated with a significant reduction in postoperative length of stay, medical cost, and postoperative complications.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Implementation of the ERAS protocol in patients undergoing elective craniotomy reduce postoperative length of stay and hospitalization costs. |
• | The application of multimodal analgesic approaches reduce moderate and severe postoperative pain, and shorten the pain duration in craniotomy. |
• | Patients who received the ERAS protocol achieved a low incidence of PONV and early postoperative functional recovery. |
• | Our study complements the gap in clinical research on the application of the ERAS protocol in neurosurgical anesthesia. |
Keywords : Enhanced recovery after surgery, Neurosurgical anesthesia, Perioperative care, Postoperative length of stay, Outcomes
Plan
Vol 76
Article 110575- février 2022 Retour au numéro
Article précédent
- Development and assessment of an efficient pediatric affect and cooperation scale
- Kristin M. Kennedy, Ellen Wang, Samuel T. Rodriguez, Jimmy Qian, Michael Khoury, Madison N. Kist, Christian Jackson, Romy Yun, Thomas J. Caruso
- Exploratory study of VVZ-149, a novel analgesic molecule, in the affective component of acute postoperative pain after laparoscopic colorectal surgery
- Srdjan S. Nedeljkovic, Inkyung Song, Xiaodong Bao, Jose L. Zeballos, Darin J. Correll, Yi Zhang, Johanna S. Ledley, Ashish Bhandari, Xiang Bai, Sang Rim Lee, Sunyoung Cho
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?