Volumetric Capnography at 36 Weeks Postmenstrual Age and Bronchopulmonary Dysplasia in Very Preterm Infants - 20/01/22
, Roland Gerull, MD 1, 2, ∗, Emanuela Zannin, PhD 3, Sotirios Fouzas, MD 4, Sven M. Schulzke, MD, MSc 1Abstract |
Objectives |
To assess the feasibility of volumetric capnography in spontaneously breathing very preterm infants at 36 weeks postmenstrual age (PMA) and its association with clinical markers of lung disease including the duration of respiratory support and bronchopulmonary dysplasia (BPD).
Study design |
We obtained mainstream volumetric capnography measurements in 143 very preterm infants at 36 weeks PMA. BPD was categorized into no, mild, moderate, and severe according to the 2001 National Heart, Lung and Blood Institute workshop report. Normalized capnographic slopes of phase II (SnII) and phase III (SnIII) were calculated. We assessed the effect of BPD, duration of respiratory support, and duration of supplemental oxygen on capnographic slopes.
Results |
SnIII was steeper in infants with moderate to severe BPD (76 ± 25/L) compared with mild (31 ± 20/L) or no BPD (26 ± 18/L) (P < .001). The association of SnIII with moderate to severe BPD persisted after adjusting for birth weight z-score, respiratory rate, and airway dead space to tidal volume ratio. The diagnostic usefulness of SnIII to discriminate between infants with and without moderate to severe BPD was high (area under the curve, 0.94; 95% CI, 0.89-0.99).
Conclusions |
Volumetric capnography is feasible in spontaneously breathing preterm infants at 36 weeks PMA and reflects the degree of lung disease. This promising bedside lung function technique may offer an objective, continuous physiological outcome measure for assessment of BPD severity.
Trial registration |
ClinicalTrials.gov: NCT02083562.
Le texte complet de cet article est disponible en PDF.Keywords : infant, premature, respiratory function tests, bronchopulmonary dysplasia, capnography
Abbreviations : BPD, BPD36, CO2, KPIv, PMA, RR, SII, SIII, SnII, SnIII, V'/Q', VD,aw, VT
Plan
| Supported by a research grant from Fondazione Ettore e Valeria Rossi, Switzerland to R.G. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors declare no conflict of interest. |
Vol 241
P. 97 - février 2022 Retour au numéro
Article précédent
- Parenting and Neurobehavioral Outcomes in Children Born Moderate-to-Late Preterm and at Term
- Grace E. McMahon, Karli Treyvaud, Megan M. Spencer-Smith, Alicia J. Spittle, Katherine J. Lee, Lex W. Doyle, Jeanie L. Cheong, Peter J. Anderson
- Randomized Trial to Increase Speech Sound Differentiation in Infants Born Preterm
- Celine Richard, Arnaud Jeanvoine, Ann R. Stark, Kaleigh Hague, Caitlin Kjeldsen, Nathalie L. Maitre
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?