Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months - 27/02/22
, I. Elkaibi c, G. Péan de Ponfilly b, d, H. Daikha c, A. Bouzid e, A. Guihot e, f, N. Castreau g, P. Pradere h, H. Ketatni c, A. Mondragon g, i, G. Hayem i, J. Le Pavec h, S. Laplanche c, A. Le Monnier b, d
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Highlights |
• | Anti-nucleocapsid IgG index seemed to be related to the healthcare workers’ age. |
• | 90.5% of healthcare workers had detectable anti-spike IgG after 7months. |
• | One-third of healthcare workers reported persistent symptoms consistent with a diagnosis of post-acute COVID-19 syndrome. |
Abstract |
Objectives |
We aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital.
Methods |
Determination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7months.
Results |
We included 3062 HCWs; 256 (8.4%) were positive for anti-SARS-CoV-2 nucleocapsid IgG. Among them, early decrease in the anti-nucleocapsid antibody index was observed between the first (S1) and second (S2) serology samplings in 208 HCWs (84.2%). The initial anti-nucleocapsid IgG index seemed to be related to the HCWs’ age. Seventy-four HCWs were included in the 7-month cohort study. Among them, 69 (90.5%) had detectable anti-spike IgG after 7months and 24 (32.4%) reported persistent symptoms consistent with post-acute COVID-19 syndrome diagnosis.
Conclusion |
The prevalence of serological positivity among HCWs was 6.7%. Infection should be followed by vaccination because of antibody decrease.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, COVID-19, Healthcare workers, Vaccination, Anti-spike IgG
Plan
Vol 52 - N° 2
P. 68-74 - mars 2022 Retour au numéro
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