Low and moderate grade retroperitoneal liposarcoma: Is adjuvant radiotherapy associated with improved survival in patients undergoing R1 resection? - 06/04/22
Abstract |
Background |
Few studies evaluate the efficacy of adjuvant radiotherapy (aXRT) in patients with retroperitoneal liposarcoma undergoing resection to histologically positive (R1) margins.
Methods |
We queried the National Cancer Database to identify patients undergoing R1 resection for localized, large (>5 cm) low and moderate grade retroperitoneal liposarcoma between 2004 and 2016. Kaplan Meier method was used to compare overall survival (OS) for patients receiving aXRT to a 1:2 propensity-matched cohort of patients undergoing resection alone.
Results |
A total of 322 (76.5%) patients underwent R1 resection alone, while 99 (23.5%) underwent resection followed by aXRT. The 99 receiving aXRT were successfully 1:2 propensity-score matched to 198 undergoing resection alone. There was no difference in 5-year OS between matched cohorts (69.7% vs 76.2%, p = 0.40).
Conclusions |
In patients undergoing R1 resection of moderate- and well-differentiated retroperitoneal liposarcoma, use of aXRT is not associated with an improvement in OS.
Le texte complet de cet article est disponible en PDF.Highlights |
• | No survival benefit from adjuvant radiotherapy in this subpopulation. |
• | Academic centers less likely to utilize adjuvant radiotherapy in this population. |
• | Female patients were less likely to receive adjuvant radiotherapy. |
Résumé |
Summary sentences: In this National Cancer Database analysis of 421 patients with large, low grade retroperitoneal liposarcoma resected to microscopically positive margins, there was no significant difference in overall survival between those treated with adjuvant radiotherapy (aXRT) and those undergoing resection alone. This trend remained after 1:2 propensity matching 99 patients in the aXRT cohort to 198 undergoing resection alone.
Le texte complet de cet article est disponible en PDF.Keywords : Retroperitoneal liposarcoma, Adjuvant radiotherapy, Margin-positive resection, Overall survival
Plan
Vol 223 - N° 3
P. 527-530 - mars 2022 Retour au numéro
Article précédent
- Small-sized gastrointestinal stromal tumors: Should expectant management be the preferred approach to care?
- Low and moderate grade retroperitoneal liposarcoma: Is adjuvant radiotherapy associated with improved survival in patients undergoing R1 resection?
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