Treatment differences at high volume centers and low volume centers in non-metastatic and metastatic adrenocortical carcinoma - 06/04/22
, Simon A. Holoubek e , Amna M. Khokar c , Kristine M. Kuchta d , Tricia A. Moo-Young a, b , Richard A. Prinz a, b , David J. Winchester a, b Abstract |
Background |
Adrenocortical carcinoma (ACC) is rare with poor survival. Do treatment and outcomes vary by volume?
Methods |
NCDB (2004–2017) was searched for patients with ACC. High-volume centers (HVCs) were defined by ≥ 15 ACC and low-volume centers by 
7 total cases. Multivariable Cox and logistic regression analysis were performed.
Results |
ACC patients at HVCs were significantly more likely to have surgery, chemotherapy, and had lower 90-day readmission. HVCs were significantly more likely than LVCs to administer chemotherapy to surgical NonMetastatic (NM)-ACC patients. There was no significant difference in overall survival (OS), 90-day mortality, length of stay, or radiation treatments between the two. Operative Metastatic (M)-ACC at HVC had significantly improved OS, more chemotherapy administered, and lower 90-day mortality.
Conclusion |
NM-ACC and M-ACC treated at HVCs were more likely to have surgery and multimodality therapy. NM-ACC having surgery at HVCs and LVCs had similar OS. M-ACC at HVCs had improved OS and 90-day mortality.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Operative stage 4 adrenocortical cancer at high volume centers had better survival. |
• | Adrenocortical carcinoma at high volume centers more likely to have surgery. |
• | Adrenocortical carcinoma at high volume centers more likely to have chemotherapy. |
Keywords : Adrenocortical carcinoma, High volume center, Low volume center, Overall survival
Plan
| ☆ | Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
Vol 223 - N° 3
P. 582-586 - mars 2022 Retour au numéro
Article précédent
- Masculinizing chest surgery for gender affirmation: A retrospective study of outcomes and patient reported satisfaction
- Treatment differences at high volume centers and low volume centers IN NON -metastatic and metastatic adrenocortical carcinoma
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