Bleeding Episodes in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Undergoing Very Early Versus Standard Care Invasive Examination (from the Very EaRly vs Deferred Invasive Evaluation Using Computerised Tomography [VERDICT] Trial) - 08/04/22
, Henning Kelbæk, MD, DMSc c, Klaus F. Kofoed, MD, DMSc a, b, Lars V. Køber, MD, DMSc a, b, Peter Riis Hansen, MD, DMSc b, d, Christian Torp-Pedersen, MD, DMSc e, Hanne Elming, MD, PhD c, b, Gunnar Gislason, MD, DMSc b, d, f, Dan E. Høfsten, MD, PhD a, Thomas Engstrøm, MD, DMSc a, b, Lene Holmvang, MD, DMSc a, bRésumé |
Bleeding is known to influence the prognosis in patients with acute coronary syndromes. In this predefined secondary outcome analysis of the Very EaRly vs Deferred Invasive evaluation using Computerized Tomography (VERDICT) trial, we investigated whether a very early invasive coronary angiography (ICA), compared with one performed within 48 to 72 hours (standard care), was associated with fewer serious bleedings. Furthermore, we tested the association between demographic data including GRACE score and serious bleedings as well as bleedings and mortality. In the 2,147 patients included in the main study, bleedings within 30 days of admission were assessed based on Thrombolysis In Myocardial Infarction and Bleeding Academic Research Consortium criteria. Differences were calculated by cumulative incidence methods and Grays test. Variables associated with bleeding and mortality were estimated by Cox proportional hazard models. Serious (Bleeding Academic Research Consortium 3abc) bleeding rates were low (15 [1.4%, standard] vs 12 [1.2%, early], p = 0.56). There were no fatal bleedings or serious bleedings before ICA in either group. By multivariate analysis, there was no difference in bleedings between the 2 groups. Female gender (hazard ratio [HR] 2.7, 95% confidence interval [CI] 1.2 to 6.4; p = 0.02), anemia (HR 7.0, 95% CI 2.8 to 17.0; p <0.001), and increasing blood pressure (HR 1.3, 95% CI 1.1 to 1.5; p = 0.01) were individually associated with serious bleeding, whereas GRACE score >140 was not (HR 1.03, 95% CI 0.4 to 2.9; p = 0.96). In conclusion, serious bleedings were few, and there were none before ICA in either group. A very early invasive strategy did not reduce serious bleedings within 30 days, which was associated with female gender, increasing blood pressure, and anemia.
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| The Danish Agency for Science, Technology and Innovation; the Danish Council for Strategic Research; and the research council at Rigshospitalet supported the study but did not have any part in designing the study, study conduct, data analysis, data interpretation, or writing of this report. |
Vol 170
P. 10-16 - mai 2022 Retour au numéro
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