The impact of COVID-19 vaccination on case fatality rates in a city in Southern Brazil - 28/04/22
, Aline M. Susuki, MSc c, André S. Olak, MSc c, Rodrigo R. Pescim, PhD a, Maria F.A.I. Tomimatsu, MSc d, Cilio J. Volce d, Maria A.Z. Neves, BSc d, Fernanda F. Silva d, Simone G. Narciso, BSc d, Michael Aschner, PhD e, Monica M.B. Paoliello, PhD e, Mariana R. Urbano, PhD a
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Highlights |
• | Vaccinated populations experience lower fatality rates than non-vaccinated populations. |
• | Full vaccination predicts lower fatality rates, regardless of age range. |
• | The age composition of cases has a significant effect on the variation in observed case fatality rates. |
• | Differences in case fatality rates across populations provide important insight for monitoring the spread of COVID-19. |
Résumé |
Background |
Recent studies have established that vaccination plays a significant role in reducing COVID-19-related deaths. Here, we investigated differences in COVID-19 case fatality rates (CFRs) among vaccinated and unvaccinated populations, and analyzed whether the age composition of confirmed cases has a significant effect on the variations in the observed CFRs across these groups.
Methods |
The study considered 59,853 confirmed cases and 1,687 deaths from COVID-19, reported between January 1 to October 20, 2021, by the Health Department of Londrina, a city in Southern Brazil. We used Negative Binomial regression models to estimate CFRs according to vaccination status and age range.
Results |
There are significant differences between the CFR for fully vaccinated and unvaccinated populations (IRR = 0.596, 95% CI [0.460 - 0.772], P < .001). Vaccinated populations experience fatality rates 40.4% lower than non-vaccinated. In addition, the age composition of confirmed cases explains more than two-thirds of the variation in the CFR between these 2 groups.
Conclusions |
Our novel findings reinforce the importance of vaccination as an essential public health measure for reducing COVID-19 fatality rates in all age groups. The results also provide means for accurately assessing differences in CFRs across vaccinated and unvaccinated populations. Such assessment is essential to inform and determine appropriate containment and mitigation interventions in Brazil and elsewhere.
Le texte complet de cet article est disponible en PDF.Key Words : COVID-19, Vaccination, Demography, Public health
Plan
| Conflicts of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Funding/support: This work was supported by CAPES – Coordination for the Improvement of Higher Education Personnel [Financing code 001]. |
Vol 50 - N° 5
P. 491-496 - mai 2022 Retour au numéro
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