Diabetes influences other chronic medical conditions and is influenced by each in turn through multifactorial pathways. These comorbid conditions have a direct relationship with diabetes and can increase the severity of diabetes and the risk of various complications. Each of these comorbidities has unique recommendations for pharmaceutical treatment. However, guidelines for all of these comorbidities also include lifestyle interventions as first-line treatment. Recent research has shown that diabetic medications may play a direct role in treating some of these comorbidities. This article focuses on the best-known comorbid diseases associated specifically with type 2 diabetes and their co-management.