The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach - 25/05/22
Doi : 10.1016/j.jaac.2022.03.008
Elisabet Blok, BSc, Sander Lamballais, MSc, Laia Benítez-Manzanas, PhD, Tonya White, MD, PhD ⁎ 
Erasmus MC University Medical Center–Sophia Children’s Hospital, Rotterdam, the Netherlands
∗Correspondence to Tonya White, MD, PhD, MSc Eng, Erasmus MC University Medical Center–Sophia Children’s Hospital, Kamer KP-2869, Postbus 2060, 3000 CB Rotterdam, The NetherlandsErasmus MC University Medical Center–Sophia Children’s HospitalKamer KP-2869, Postbus 2060Rotterdam3000 CBThe Netherlands
Résumé |
The field of psychiatry increasingly highlights the importance of studying not only the influence of the brain on behavior, but also the long-term influences that the persistence of specific behaviors can have on the brain. A severe behavioral phenotype that puts children at risk for later psychopathology is the Child Behavior Checklist-Dysregulation Profile (CBCL-DP).1 In earlier work, Shaw et al.2 proposed a model in which the amygdala, nucleus accumbens, and orbitofrontal cortex, structures involved in the bottom-up response to emotional stimuli, are related to emotion dysregulation. Additionally, 3 key limbic white matter tracts have also been shown to be associated with CBCL-DP symptoms: the uncinate fasciculus, cingulum bundle, and forceps minor.3,4
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| This work is supported by the Sophia Children’s Hospital Research Foundation (SSWO) project numbers S18-68 and S20-48 and the Netherlands Organization for Health Research and Development (ZonMw) TOP project number 91211021. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, ZonMw, the Netherlands Organization for Scientific Research (NWO), and the Ministry of Health, Welfare and Sport and is conducted by the Erasmus Medical Center in close collaboration with the Faculty of Social Sciences of the Erasmus University Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. |
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| The research was performed with permission from the Medical Ethics Review Committee Erasmus MC and Institutional Review Boards of individual sites of the Adolescent Brain Cognitive Development (ABCD) Study. |
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| Consent has been provided for descriptions of specific patient information. |
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| Jan van der Ende, PhD, of Erasmus University Rotterdam, served as the statistical expert for this research. |
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| Author Contributions |
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| Conceptualization: Blok, White |
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| Data curation: Blok, White |
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| Funding acquisition: White |
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| Methodology: Blok, Lamballais, White |
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| Project administration: White |
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| Resources: White |
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| Supervision: White |
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| Visualization: Blok |
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| Writing – original draft: Blok |
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| Writing – review and editing: Lamballais, Benítez-Manzanas, White |
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| Part of the data that will be used in the preparation of this article will be obtained from the ABCD Study (abcdstudy.org), held in the National Institute of Mental Health Data Archive (NDA). This is a multisite, longitudinal study designed to recruit more than 10,000 children age 9–10 and follow them over 10 years into early adulthood. The ABCD Study is supported by the National Institutes of Health (NIH) and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, and U24DA041147. A full list of supporters is available at federal-partners.html. A listing of participating sites and a complete listing of the study investigators can be found at consortium_members/. ABCD consortium investigators designed and implemented the study and/or provided data, but did not and will not necessarily participate in analysis or writing of this report. This article reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. The ABCD data repository grows and changes over time. The ABCD data used in this report came from 1519007. |
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| The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. |
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| Disclosure: Dr. White has received grant or research support from the Sophia Children’s Hospital Foundation. She has served on the advisory board/DSMB of the University of Bergen Center for Brain Plasticity. She has served on the editorial board of Neuroinformatics and as Editor-in-Chief of Aperture Neuro. Ms. Blok, Dr. Lamballais, and Ms. Benítez-Manzanas have reported no biomedical financial interests or potential conflicts of interest. |
© 2022
Publié par Elsevier Masson SAS.
Vol 61 - N° 6
P. 830-831 - juin 2022 Retour au numéro
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