MIR4435-2HG: A newly proposed lncRNA in human cancer - 27/05/22

Doi : 10.1016/j.biopha.2022.112971

Menggang Zhang ^a,^b,^c,^d,^{^{1
These authors contributed equally to this work.}}, Xiao Yu ^a,^b,^c,^d,^{^{1
These authors contributed equally to this work.}}, Qiyao Zhang ^a,^b,^c,^d, Zongzong Sun ^e, Yuting He ^a,^b,^c,^d,^⁎ , Wenzhi Guo ^a,^b,^c,^d,^⁎
^a Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
^b Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
^c Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China
^d Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China
^e Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan, China

^⁎Correspondence to: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshedong Road, Erqi District, Zhengzhou 450052, China.Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou UniversityNo. 1 Jianshedong Road, Erqi DistrictZhengzhou450052China

Abstract

Long non-coding RNAs (lncRNAs) play important roles in the occurrence and progression of tumors. Extensive research has contributed to the current understanding of the critical roles played by lncRNAs in various cancers. LncRNA MIR4435-2HG has been found to be crucial in many cancers, such as breast, cervical, colorectal, and gastric cancer. Expression of MIR4435-2HG is generally upregulated in cancers and MIR4435-2HG participates in many biological functions through molecular mechanism of competitive endogenous RNA networks. This review profiles recent research findings on the expression, functions, mechanism, and clinical value of MIR4435-2HG in cancer, and serves as a reference for further MIR4435-2HG-related research and clinical trials.

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Keywords : Long non-coding RNA, MIR4435-2HG, Prognosis, Cellular process, Signaling pathway

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Article 112971- juin 2022 Retour au numéro

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MIR4435-2HG: A newly proposed lncRNA in human cancer - 27/05/22

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