The interaction between ETS transcription factor family members and microRNAs: A novel approach to cancer therapy - 27/05/22
Abstract |
In cancer biology, ETS transcription factors promote tumorigenesis by mediating transcriptional regulation of numerous genes via the conserved ETS DNA-binding domain. MicroRNAs (miRNAs) act as posttranscriptional regulators to regulate various tumor-promoting or tumor-suppressing factors. Interactions between ETS factors and miRNAs regulate complex tumor-promoting and tumor-suppressing networks. This review discusses the progress of ETS factors and miRNAs in cancer research in detail. We focused on characterizing the interaction of the miRNA/ETS axis with competing endogenous RNAs (ceRNAs) and its regulation in posttranslational modifications (PTMs) and the tumor microenvironment (TME). Finally, we explore the prospect of ETS factors and miRNAs in therapeutic intervention. Generally, interactions between ETS factors and miRNAs provide fresh perspectives into tumorigenesis and development and novel therapeutic approaches for malignant tumors.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | ETS factors and microRNAs are abnormally expressed in cancer. |
• | The miRNA/ETS axis regulates tumorigenesis and progression at multiple levels. |
• | The miRNA/ETS axis may be a novel therapeutic target for cancer therapy. |
Abbreviations : ZEB1, EMT, Rb1, TIMP-1, EGF, TGF-β, MAPK, ERK, JNK
Keywords : ETS, Transcription factor, MiRNA, CeRNA, The tumor microenvironment, Cancer therapy
Plan
Vol 150
Article 113069- juin 2022 Retour au numéro
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