Repeat endoscopic submucosal dissection as salvage treatment for local recurrence of esophageal squamous cell carcinoma after initial endoscopic submucosal dissection - 14/06/22
Abstract |
Background and Aims |
Local recurrence of esophageal squamous cell carcinoma (ESCC) after endoscopic resection does not have an established treatment. The efficacy and safety of repeat endoscopic submucosal dissection (ESD) for recurrent ESCC were determined in the study.
Methods |
Forty-three consecutive patients with 45 locally recurrent superficial ESCC lesions undergoing repeat ESD and 909 first ESD lesions for propensity score matching (PSM) at Zhongshan Hospital between January 2011 and January 2020 were retrospectively enrolled. After PSM (1:2), operation-related parameters were compared between repeat ESD and first ESD. In the repeat ESD group, the Kaplan-Meier method and log-rank tests were used for identification of risk factors for local recurrence after repeat ESD.
Results |
As compared with propensity score–matched first ESD, rates of complete resection (86.7% vs 97.8%, P = .02) and curative resection (86.7% vs 96.7%, P = .06) were lower and procedure duration (54.8 ± 21.7 minutes vs 46.2 ± 20.6 minutes, P = .67) and hospital stay (4.3 ± 1.8 days vs 2.9 ± 1.4 days, P = .25) were longer in the repeat ESD group. The en-bloc resection rate (93.3% vs 98.8%, P > .11) remained comparable. Adverse events including bleeding (4.4% vs 0%, P = .11), perforation (.0% vs .0%, P > .99), and stricture (6.7% vs 2.2%, P = .33) presented with no difference. The 5-year overall survival rate and recurrence-free survival rate for repeat ESD was 100% and 86.0%, respectively. Multiplicity was significantly associated with recurrence after repeat ESD (P = .01).
Conclusions |
Repeat esophageal ESD showed favorable short- and long-term outcomes and thus provides an alternative choice for recurrent superficial ESCC.
Le texte complet de cet article est disponible en PDF.Abbreviations : ESCC, ESD, LVI, PSM
Plan
| DISCLOSURE: All authors disclosed no financial relationships. Research support for this study was provided by grants from the National Key R&D Program of China (2019YFC1315800, P.-H. Zhou), National Natural Science Foundation of China (81873552, Q.-L. Li, 82003074, J.-Q. Xu, and 81670483, P.-H. Zhou), Shanghai Rising-Star Program (19QA1401900, Q.-L. Li), Major Project of Shanghai Municipal Science and Technology Committee (18ZR1406700, Q.-L. Li, 19441905200, W.-F. Chen, and 16DZ2280900, L.-Q. Yao), and Shanghai Sailing Program of Shanghai Municipal Science and Technology Committee (2018YF1403700, J.-Q. Xu). |
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| DIVERSITY, EQUITY, AND INCLUSION: We worked to ensure gender balance in the recruitment of human subjects. We worked to ensure ethnic or other types of diversity in the recruitment of human subjects. One or more of the authors of this paper self-identifies as an under-represented gender minority in science. While citing references scientifically relevant for this work, we actively worked to promote gender balance in our reference list. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work |
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| If you would like to chat with an author of this article, you may contact Dr Li at li.quanlin@zs-hospital.sh.cn or Dr Zhou at zhou.pinghong@zs-hospital.sh.cn. |
Vol 96 - N° 1
P. 18 - juillet 2022 Retour au numéro
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