Relationship Between Postnatal Pulmonary Arterial Pressure and Altered Diastolic Function in Neonates with Down Syndrome - 16/06/22
, Neidin Bussmann, PhD 1, Colm Breatnach, PhD 1, Philip T. Levy, MD 2, 3, Eleanor Molloy, PhD 4, 5, Jan Miletin, PhD 4, Anna Curley, MD 6, Naomi McCallion, MD 1, 7, Orla Franklin, MRCPCH 8, Afif F. El-Khuffash, MD 1, 7Abstract |
Objective |
To assess the influence of diastolic dysfunction on the evolution of pulmonary hypertension in neonates with Down Syndrome over the early newborn period.
Study design |
This was a prospective observational cohort study. Echocardiography was performed three times over the first week of life in both Down syndrome and control cohorts. Measurements of pulmonary arterial pressure in addition to left ventricular (LV) and right ventricular systolic and diastolic function were collected.
Results |
Seventy babies with Down syndrome and 60 control infants were enrolled. Forty-eight of the infants with Down syndrome (69%) were born with congenital heart disease (CHD). Echocardiography surrogates of pulmonary hypertension and myocardial function remained significantly impaired in the Down syndrome group in comparison with control infants (all P < .01). In the Down syndrome group, LV early diastolic strain rate was independently associated with measures of pulmonary hypertension while controlling for gestational age, cesarean delivery, and the presence of CHD (P < .01).
Conclusions |
Intrinsic LV diastolic impairment is directly associated with higher indices of pulmonary hypertension in infants with Down syndrome and may be a contributing factor to its evolution.
Le texte complet de cet article est disponible en PDF.Keywords : Down syndrome, diastolic function, pulmonary hypertension
Abbreviations : ASD, CHD, LV, EI, PAAT, PAATi, PDA, PVR, RV, RVET
Plan
| Funding for this work was provided by the Health Research Board Ireland (NCHF-2017-005) and the National Children's Research Centre (D/17/7). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest. |
Vol 245
P. 172 - juin 2022 Retour au numéro
Article précédent
- Validity Evidence for a Novel, Comprehensive Bag–Mask Ventilation Assessment Tool
- Allison M. Whalen, Matthew H. Merves, Priyanka Kharayat, James S. Barry, Kristen M. Glass, Robert A. Berg, Taylor Sawyer, Vinay Nadkarni, Donald L. Boyer, Akira Nishisaki
- Use of Cotton Balls in Diapers for Collection of Urine Samples Impacts the Analysis of Routine Chemistry Tests: An Evaluation of Cotton Balls, Diapers, and Chemistry Analyzers
- Stefani N. Thomas, Heather M. Stieglitz, Sarah Hackenmueller, Brenda Suh-Lailam, Amy L. Pyle-Eilola
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?