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Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study - 17/06/22

Doi : 10.1016/j.resmer.2022.100900 
Aykut Cilli a, , Ismail Hanta b, Fatih Uzer a, Funda Coskun c, Can Sevinc d, Pelin Pınar Deniz b, Mehmet Parlak a, Ersoy Altunok b, Kemal Can Tertemiz d, Ahmet Ursavas c
a Department of Respiratory Disease, Akdeniz University, Antalya, Turkey 
b Department of Respiratory Disease, Cukurova University, Adana, Turkey 
c Department of Respiratory Disease, Uludag University, Bursa, Turkey 
d Department of Respiratory Disease, Dokuz Eylul University, Izmır, Turkey 

Corresponding author at: Akdeniz University, Department or Respiratory Disease, Antalya, Turkey.Akdeniz UniversityDepartment or Respiratory DiseaseAntalyaTurkey

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ABSTRACT

Background

There are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe the characteristics and outcomes of IPF patients confirmed COVID-19 infection.

Methods

In this retrospective, multi-center, cohort study, patients from 4 hospital medical records with known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.

Results

Records for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65±10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated with hospitalization or mortality.

Conclusions

IPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain key to protect IPF patients.

Le texte complet de cet article est disponible en PDF.

Key words : Interstitial lung disease, Idiopathic pulmonary fibrosis, Outbreak, Pandemic, SARS-CoV-2


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Vol 81

Article 100900- mai 2022 Retour au numéro
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