Radiation-Induced Cardiac Dysfunction : Optimizing Radiation Delivery and Postradiation Care - 17/06/22

Doi : 10.1016/j.hfc.2022.02.012

Lauren N. Pedersen, PhD ^a, Menka Khoobchandani, PhD ^a, Randall Brenneman, MD, PhD ^a,^c, Joshua D. Mitchell, MD, MSCI ^b,^c,^d, Carmen Bergom, MD, PhD ^a,^b,^c,^⁎
^a Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, USA
^b Cardio-Oncology Center of Excellence, Washington University in St. Louis, St Louis, MO, USA
^c Alvin J. Siteman Center, Washington University in St. Louis, St Louis, MO, USA
^d Division of Cardiology, Department of Medicine, Washington University in St. Louis, St Louis, MO, USA

^∗Corresponding author. Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110.Department of Radiation OncologyWashington University School of Medicine4921 Parkview PlaceSt. LouisMO63110

Résumé

Radiation therapy (RT) is part of standard-of-care treatment of many thoracic cancers. More than 60% of patients receiving thoracic RT may eventually develop radiation-induced cardiac dysfunction (RICD) secondary to collateral heart dose. This article reviews factors contributing to a thoracic cancer patient's risk for RICD, including RT dose to the heart and/or cardiac substructures, other anticancer treatments, and a patient's cardiometabolic health. It is also discussed how automated tracking of these factors within electronic medical record environments may aid radiation oncologists and other treating physicians in their ability to prevent, detect, and/or treat RICD in this expanding patient population.

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Keywords : Radiation, Cancer, Electronic medical record, Breast cancer, Lung cancer, Deep inspiration breath hold, Implementation science, Radiation-induced cardiac dysfunction