Psychiatric Outcomes, Functioning, and Participation in Extremely Low Gestational Age Newborns at Age 15 Years - 27/06/22
, David Cochran, MD, PhD a, Sohye Kim, PhD a, Isha Jalnapurkar, MD a, Robert M. Joseph, PhD b, Stephen R. Hooper, PhD c, Hudson P. Santos, PhD, RN c, Hongyu Ru, PhD c, Lauren Venuti, MSW a, Rachana Singh, MD, MS d, Lisa K. Washburn, MD e, Semsa Gogcu, MD, MPH e, Michael E. Msall, MD f, Karl C.K. Kuban, MD b, Julie V. Rollins, MA c, Shannon G. Hanson, PhD, MPH e, Hernan Jara, PhD b, Steven L. Pastyrnak, PhD g, Kyle R. Roell, PhD c, Rebecca C. Fry, PhD c, T. Michael O’Shea, MD, MPH cfor the
ELGAN Study Investigators
Abstract |
Objective |
To evaluate the prevalence, co-occurrence, sex differences, and functional correlates of DSM-5 psychiatric disorders in 15-year-old adolescents born extremely preterm.
Method |
The Extremely Low Gestational Age Newborns (ELGAN) Study is a longitudinal study of children born <28 weeks gestation. At age 15, 670 adolescents completed the Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI-KID), the Youth Self-Report, a disability scale of participation in social roles, and cognitive testing. Parents completed a family psychiatric history questionnaire.
Results |
The most prevalent psychiatric disorders were anxiety, attention-deficit/hyperactivity disorder, and major depression. More girls met criteria for anxiety than boys. Though 66% of participants did not meet criteria for a psychiatric disorder, 15% met criteria for 1, 9% for 2, and 8% for ≥3 psychiatric disorders. Participants with ≥2 psychiatric disorders were more likely to have repeated a grade, to have an individualized educational program, and to have a lower nonverbal IQ than those with no psychiatric disorders. Participants with any psychiatric disorder were more likely to use psychotropic medications; to have greater cognitive and functional impairment; and to have mothers who were single, were on public health insurance, and had less than a high school education. Finally, a positive family psychiatric history was identified more frequently among adolescents with ≥3 psychiatric disorders.
Conclusion |
Among adolescents born extremely preterm, anxiety, major depression, and attention-deficit/hyperactivity disorder were the most prevalent psychiatric disorders at age 15. Adolescents with >1 psychiatric disorder were at increased risk for multiple functional and participatory challenges.
Le texte complet de cet article est disponible en PDF.Key words : adolescents, functioning, preterm, prevalence, psychiatric disorders
Plan
| This article was reviewed under and accepted by Ad Hoc Editor Cynthia Rogers, MD. |
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| This study was supported by the National Institute of Neurological Disorders and Stroke (grant numbers 5U01NS040069-05 and 2R01NS040069-06-09), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant numbers 5R01 HD092374-05 and 5P30HD018655-34), and the Office of the National Institutes of Health Director (grant number 5UH3OD023348-06, former number 4UG3OD023348-03). |
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| Author Contributions |
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| Conceptualization: Frazier, Cochran, Joseph, Hooper, Santos, Venuti, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Hanson, Pastyrnak, Fry, O’Shea |
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| Data curation: Frazier, Santos, Ru, Fry, O’Shea |
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| Formal analysis: Frazier, Joseph, Hooper, Santos, Ru, Kuban, Roell, Fry, O’Shea |
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| Funding acquisition: Frazier, Joseph, Hooper, Santos, Kuban, Rollins, Jara, Fry, O’Shea |
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| Investigation: Frazier, Cochran, Joseph, Hooper, Santos, Venuti, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Hanson, Jara, Pastyrnak, Fry, O’Shea |
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| Methodology: Frazier, Cochran, Kim, Jalnapurkar, Joseph, Hooper, Santos, Ru, Venuti, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Hanson, Pastyrnak, Roell, Fry, O’Shea |
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| Project administration: Frazier, Cochran, Joseph, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Hanson, Jara, Pastyrnak, Fry, O’Shea |
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| Resources: Frazier, Singh, Washburn, Gogcu, Msall, Pastyrnak, Fry, O’Shea |
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| Software: Fry, O’Shea |
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| Supervision: Frazier, Cochran, Joseph, Hooper, Venuti, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Pastyrnak, Fry, O’Shea |
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| Validation: Frazier, Cochran, Kim, Jalnapurkar, Joseph, Hooper, Santos, Ru, Venuti, Kuban, Rollins, Hanson, Jara, Roell, Fry, O’Shea |
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| Visualization: Frazier, Cochran, Kim, Jalnapurkar, Joseph, Hooper, Santos, Ru, Venuti, Kuban, Rollins, Hanson, Jara, Fry, O’Shea |
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| Writing – original draft: Frazier, Cochran, Kim, Jalnapurkar, Ru |
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| Writing – review and editing: Frazier, Cochran, Kim, Jalnapurkar, Joseph, Hooper, Santos, Ru, Venuti, Singh, Washburn, Gogcu, Msall, Kuban, Rollins, Hanson, Jara, Pastyrnak, Roell, Fry, O’Shea |
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| The ELGAN (Extremely Low Gestational Age Newborns) Study website is available at: www.elganstudy.org/. |
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| The authors are especially grateful to the participants and their families whose commitment to the ELGAN Study has made this work possible. The authors acknowledge the inspiration, guidance, and collaboration of all the ELGAN research investigators and study staff. The authors thank David Sheehan, MD, MBA, of the University of South Florida College of Medicine, for his consultation regarding the use of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). |
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| Disclosure: Dr. Frazier has received grant or research support from the National Institute of Mental Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Healix, and Autism Speaks. She has served on the editorial board of the Harvard Review of Psychiatry and as associate editor of the Journal of Child and Adolescent Psychopharmacology. Dr. Singh has served on an advisory board for Emergent BioSolutions. Drs. Cochran, Kim, Jalnapurkar, Joseph, Hooper, Santos, Ru, Washburn, Gogcu, Msall, Kuban, Hanson, Jara, Pastyrnak, Roell, Fry, and O’Shea and Mss. Venuti and Rollins have reported no biomedical financial interests or potential conflicts of interest. |
Vol 61 - N° 7
P. 892 - juillet 2022 Retour au numéro
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