The role of metabolic reprogramming in cancer metastasis and potential mechanism of traditional Chinese medicine intervention - 31/08/22
, Fangyuan Wang a, 1 , Xianbin Kong b , Qingbo Li a , Haoyang Shi a , Shuang Zhao a , Wen Li a , Yu Li a , Jingyan Meng b, ⁎ Abstract |
Metabolic reprogramming is one of the most prominent features underlying cancer cells progression and metastasis.Traditional Chinese medicine (TCM) has been widely used in the clinical treatment of cancer, with the advantages of multi-pathway, multi-target, multi-component anti-tumor pharmacological effects and low risk of adverse effects. However, the mechanisms underlying the anti-tumor effects of TCM are not fully understood, especially on cellular metabolic reprogramming. In this review, we summarize the role of glucose, lipid and amino acid metabolism in cancer metastasis, which is key in cancer cells and tumor micro-environment (TME) cell metabolism. Furthermore, we reviewed the potential mechanisms by which, most bioactive TCM compounds suppress cancer metastasis by regulating metabolic reprogramming and the possibility of sensitizing other anti-tumor drugs. TCM and its bioactive compounds have huge prospects for clinical application in the treatment of cancer metastasis. Unfortunately, little is currently known about the regulatory effects of Chinese herbal medicines and their bioactive compounds on the metabolic reprogramming of cancer cells and the combination therapy for cancers. This review provides novel insights into the regulation of metabolic reprogramming by TCM in combination with other anti-tumor drugs against cancer metastasis and the possibility of becoming sensitizers for other anti-tumor drugs.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
TCM and its bioactive compounds suppress cancer metastasis and sensitize other anti-tumor drugs by regulating metabolic reprogramming of cells, including cancer cells and tumor micro-environment cells.
Highlights |
• | The role of metabolic reprogramming during cancer metastasis. |
• | The potential mechanisms of metabolic reprogramming by TCM during cancer metastasis. |
• | TCM may be an sensitizer for other anti-tumor drugs. |
• | TCM combined with other anti-tumor drugs can suppress metastasis by regulating metabolic reprogramming. |
Abbreviations : TCM, TME, OXPHOS, EMT, ECM, ATP, ROS, AMPK, BC, HER 2, PDAC, NF-κB, ECR, GC, HIF, CRC, NADPH, GLDC, GLUD, SIRT, CSCs, MAPK, FABP, FATP, mTOR, SREBP, SCD, TGFβ1, siRNA, HEMA, p-ERK, Bcl-xl, SOAT, PI3K/Akt, ATGL, CCL, VEGF, MMP, CE, FA, CPT, FAO, FASN, HK, PFK, PDK, PDH, LDH, TCA, TG, TAM, NK, CAF, DC, MDSC, EC, CTL, NFAT, PPAR, PD-1, PD-L1, GFAT, IFN, M-CSF, NOS2, DON, IRE1, IDO, ABC, GS, GM-CSF, IL, G-CSF, MSR1, GRP78, JAK2, ASIC2, LXR, CXCL12, CXCR, GPD, EGCG, COVID-19
Keywords : Metabolic reprogramming, Traditional Chinese medicine, TME cells, Cancer metastasis, Tumor micro-environment
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Vol 153
Article 113376- septembre 2022 Retour au numéro
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