Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease - 31/08/22
Abstract |
Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Mesenchymal stem cell (MSC) mitochondria transfer is a potential strategy in cell therapy. |
• | Tunnel nanotubes, microvesicles, gap junctions and cell fusion are the most common patterns of MSC mitochondrial transfer. |
• | MSC mitochondria transfer is widely used in the treatment of cardiovascular injury，lung injury，brain injury，skin injury，renal injury, eye injury, etc. |
Abbreviations : MSCs, TNTs, MVs, EVs, GJs, GJCs, GJIC, Cx, Miro1, AAI, LPS, BM-MSCs, NF-κB, HUVECs, hBMSCs, TNF-α, ROS, hMSCs, H/R, NMCMs, PMVECs, ARDS, AM
Keywords : Mitochondrial transfer, Mesenchymal stem cells, Tissue damage
Plan
Vol 153
Article 113482- septembre 2022 Retour au numéro
Article précédent
- Reprogramming of central carbon metabolism in hepatocellular carcinoma
- Haoming Xia, Ziyue Huang, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
- Driving neoantigen-based cancer vaccines for personalized immunotherapy into clinic: A burdensome journey to promising land
- Ganjun Yu, Xiaobo He, Xing Li, Yanfeng Wu
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?