S'abonner

Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2? - 10/09/22

Doi : 10.1016/j.biopha.2022.113522 
Manish Dhawan a, b, , AbdulRahman A. Saied c, d, Saikat Mitra e, Fahad A. Alhumaydhi f, Talha Bin Emran g, h, , Polrat Wilairatana i,
a Department of Microbiology, Punjab Agricultural University, Ludhiana 141004, Punjab, India 
b Trafford College, Altrincham, Manchester WA14 5PQ, UK 
c National Food Safety Authority (NFSA), Aswan Branch, Aswan 81511, Egypt 
d Ministry of Tourism and Antiquities, Aswan Office, Aswan 81511, Egypt 
e Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh 
f Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia 
g Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh 
h Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh 
i Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand 

Corresponding author at: Department of Microbiology, Punjab Agricultural University, Ludhiana 141004, Punjab, India.Department of Microbiology, Punjab Agricultural UniversityLudhianaPunjab141004India⁎⁎Corresponding author at: Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.Department of Pharmacy, BGC Trust University BangladeshChittagong4381Bangladesh⁎⁎⁎Corresponding author at: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol UniversityBangkok10400Thailand

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Abstract

Since the start of the COVID-19 pandemic, numerous variants of SARS-CoV-2 have been reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid the serious containment efforts against COVID-19 that include physical measures, pharmacological repurposing, immunization, and genomic/community surveillance. Omicron variant (B.1.1.529) has been identified as a highly modified, contagious, and crucial variant among the five VOCs of SARS-CoV-2. The increased affinity of the spike protein (S-protein), and host receptor, angiotensin converting enzyme-2 (ACE-2), due to a higher number of mutations in the receptor-binding domain (RBD) of the S-protein has been proposed as the primary reason for the decreased efficacy of majorly available vaccines against the Omicron variant and the increased transmissible nature of the Omicron variant. Because of its significant competitive advantage, the Omicron variant and its sublineages swiftly surpassed other variants to become the dominant circulating lineages in a number of nations. The Omicron variant has been identified as a prevalent strain in the United Kingdom and South Africa. Furthermore, the emergence of recombinant variants through the conjunction of the Omicron variant with other variants or by the mixing of the Omicron variant's sublineages/subvariants poses a major threat to humanity. This raises various issues and hazards regarding the Omicron variant and its sublineages, such as an Omicron variant breakout in susceptible populations among fully vaccinated persons. As a result, understanding the features and genetic implications of this variant is crucial. Hence, we explained in depth the evolution and features of the Omicron variant and analyzed the repercussions of spike mutations on infectiousness, dissemination ability, viral entry mechanism, and immune evasion. We also presented a viewpoint on feasible strategies for precluding and counteracting any future catastrophic emergence and spread of the omicron variant and its sublineages that could result in a detrimental wave of COVID-19 cases.

Le texte complet de cet article est disponible en PDF.

Graphical Abstract




ga1

Le texte complet de cet article est disponible en PDF.

Highlights

The emergence of the Omicron variant and its sublineages pose a severe threat.
Significant number of mutations in the Omicron variant has been associated.
The Omicron variant might have evolved separately from all the previous variants.
Omicron and other variants may generate resistant variants to present vaccines.
Genomic surveillance and Omicron-specific vaccines are containment measures.

Le texte complet de cet article est disponible en PDF.

Keywords : COVID-19, Omicron, Variants, Sublineages, Pandemic, Vaccine effectiveness


Plan


© 2022  The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 154

Article 113522- octobre 2022 Retour au numéro
Article précédent Article précédent
  • Oncogenic roles of LINC01234 in various forms of human cancer
  • Minyu Kong, Xiao Yu, Qingyuan Zheng, Shuijun Zhang, Wenzhi Guo
| Article suivant Article suivant
  • Role of curcumin in selected head and neck lesions. Limitations on the use of the Hep-2 cell line: A critical review
  • Ludwika Piwowarczyk, Maciej Stawny, Krzysztof Piwowarczyk, Dariusz T. Mlynarczyk, Izabela Muszalska-Kolos, Malgorzata Wierzbicka, Tomasz Goslinski, Anna Jelinska

Bienvenue sur EM-consulte, la référence des professionnels de santé.

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.


Tout le contenu de ce site: Copyright © 2024 Elsevier, ses concédants de licence et ses contributeurs. Tout les droits sont réservés, y compris ceux relatifs à l'exploration de textes et de données, a la formation en IA et aux technologies similaires. Pour tout contenu en libre accès, les conditions de licence Creative Commons s'appliquent.