ESKAPE bacteria characterization reveals the presence of Acinetobacter baumannii and Pseudomonas aeruginosa outbreaks in COVID-19/VAP patients - 16/09/22
, Juan Manuel Bello-López, PhD a, ⁎
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Highlights |
• | ESKAPE bacteria was related in COVID-19/VAP patients. |
• | MDR and XDR ESKAPE bacteria were identified. |
• | Clonal dispersion of A. baumannii was detected in COVID-19/VAP patients. |
Abstract |
Introduction |
A decrease of detection of outbreaks by multidrug-resistant bacteria in critical areas has been reduced due to COVID-19 pandemic. Therefore, molecular epidemiological surveillance should be a primary tool to reveal associations not evident by classical epidemiology. The aim of this work was to demonstrate the presence of hidden outbreaks in the first wave of the COVID-19 pandemic and to associate their possible origin.
Methods |
A population of 96 COVID-19 patients was included in the study (April to June 2020) from Hospital Juárez de México. Genetic identification and antimicrobial susceptibility testing of VAP causative agents isolated from COVID-19 patients was performed. Resistance phenotypes were confirmed by PCR. Clonal association of isolates was performed by analysis of intergenic regions obtained. Finally, the association of clonal cases of VAP patients was performed by timelines.
Results |
ESKAPE and non-ESKAPE bacteria were identified as causative agents of VAP. ESKAPE bacteria were classified as MDR and XDR. Only A. baumannii and P. aeruginosa were identified as clonally distributed in 13 COVID-19/VAP patients. Time analysis showed that cross-transmission existed between patients and care areas.
Conclusions |
Acinetobacter baumannii and Pseudomonas aeruginosa were involved in outbreaks non-detected in COVID-19/VAP patients in the first wave of COVID-19 pandemic.
Le texte complet de cet article est disponible en PDF.Key Words : Bacteria ESKAPE, Ventilator associated pneumonia, COVID-19, Clonal dispersion, ERIC-PCR
Plan
| Financial support: This study is part of the project “CONACyT 313771: Análisis del efecto del ozono sobre SARS-CoV-2 como alternativa de producto desinfectante en equipos de protección del personal de salud de alta demanda” and funding of the 022 budget (year 2021) of the “Hospital Juárez de México.” This study was approved by Secretaría de Investigación y Posgrado del Instituto Politécnico Nacional (SIP 20211351, 20220818). |
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| Declaration of Competing Interest: The authors declare no conflict of interest. |
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