Precision Medicine for Idiopathic Hypersomnia - 21/09/22
Résumé |
Idiopathic hypersomnia (IH) includes a clinical phenotype resembling narcolepsy (with repeated, short restorative naps), and a phenotype with an excess of sleep, sleep drunkenness, drowsiness, and infrequent long, nonrestorative naps. Sleep tests reflect this heterogeneity. MSLTs are greater than 8 min in 2/3 of the cases and poorly repeatable. Sleep excess is better captured by extended monitoring identifying 11 to 16h of sleep/24 h. Patients with IH are young and more often female. Possible mechanisms of IH include deficiencies in arousal systems, inappropriate stimulation of sleep-inducing systems, and long biological night. Treatments now include robust studies of modafinil, clarithromycin, and sodium oxybate.
Le texte complet de cet article est disponible en PDF.Keywords : Hypersomnia, Long sleep time, Drowsiness, GABA, Modafinil, Sodium oxybate
Plan
| Sleep Med Clin 14 (2019) 333-350 j.jsmc.2019.05.007 1556-407X/19/© 2019 Elsevier Inc. All rights reserved. |
Vol 17 - N° 3
P. 379-398 - septembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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