A Practical Guide to the Diagnosis, Evaluation, and Treatment of Cutaneous T-Cell Lymphoma - 18/11/22

Doi : 10.1016/j.det.2022.07.019

Serena Shimshak, BA ^a, Olayemi Sokumbi, MD ^b,^c, Nasro Isaq, MD ^d, Amrita Goyal, MD ^e, Nneka Comfere, MD ^d,^f,^⁎
^a Mayo Clinic Alix School of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
^b Department of Dermatology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
^c Department of Laboratory Medicine and Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
^d Department of Dermatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
^e Department of Dermatology, University of Minnesota, 516 Delaware Street Southeast, Minneapolis, MN 55455, USA
^f Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA

^∗Corresponding author. Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905.Mayo Clinic200 First Street SouthwestRochesterMN55905

Résumé

Cutaneous T-cell lymphomas are a clinically and histopathologically heterogenous group of disorders, encountered in dermatologic practice. In this article, we provide a detailed practical guide to the evaluation, diagnosis, and management of common cutaneous T-cell lymphomas. Emphasis is placed on the clinical evaluation including the role of the dermatologist in the accurate assessment of body surface area involvement for disease staging, appropriate biopsy techniques, and key considerations, recent advances in the molecular genetic characteristics of disease, and common treatment approaches.

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Keywords : Mycosis fungoides, Sezary syndrome, Lymphomatoid papulosis, Large cell lymphoma, Adult T-cell leukemia/lymphoma, Gamma delta lymphoma, Peripheral T-cell lymphoma

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