Primary hyperparathyroidism after radioactive iodine therapy: Is it a distinct clinical entity? - 13/12/22
, Judy Jin b, Scott Wilhelm a, Anuja Sarode a, Christine E. Alvarado a, Ayat ElSherif b, Christopher R. McHenry cAbstract |
Background |
Radioactive iodine (RAI) treatment is considered a rare cause of primary hyperparathyroidism (pHPT).
Method |
A multi-institutional retrospective review of patients with pHPT who underwent parathyroidectomy from 1990 to 2020 was completed to evaluate the prevalence and latency time for development of RAI-associated pHPT and determine clinical differences in pHPT patients with or without prior RAI treatment.
Results |
1929 patients with sporadic pHPT underwent parathyroidectomy; 48 (2.5%) had prior RAI treatment and 1881 (97.5%) did not. RAI treatment was for thyrotoxicosis in 43 (90%) patients. Average latency was 24 years (3–59 years) and inversely correlated with age. Patients with prior RAI treatment had lower preoperative calcium and PTH levels (p < 0.0001). No significant differences were observed in age, symptoms, pathology, ectopic glands and cure rate.
Conclusion |
RAI is a potential causative factor for pHPT, accounting for 2.5% of sporadic pHPT. RAI-associated pHPT may be a less severe form of sporadic pHPT and latency inversely correlates with age.
Le texte complet de cet article est disponible en PDF.Highlights |
• | 2.5% of patients undergoing parathyroidectomy had radioactive iodine exposure. |
• | The average latency to development of RAI-induced hyperparathyroidism is 24 years. |
• | As age at the time of RAI treatment increases, the latency period decreases. |
• | Follow-up serum calcium level every 3–5 years following RAI treatment is recommended. |
Keywords : Radioiodine, RAI, Primary hyperparathyroidism, Radioiodine-associated hyperparathyroidism
Plan
Vol 225 - N° 1
P. 180-183 - janvier 2023 Retour au numéro
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